Efficient synthesis of 3-furanosyl-6′-furanosylphosphinate through a tandem sequential radical process

被引：39

作者：

Dubert, O

Gautier, A

Condamine, E

Piettre, SR ^{[1
]}

机构：

[1] Univ Rouen, IRCOV, Lab Fonct Azotees & Osygenees Complexes, CNRS,UMR 6014, F-76821 Mont St Aignan, France

[2] Univ Rouen, IRCOV, Lab Chim Organ & Biol Struct, CNRS,UMR 6014, F-76821 Mont St Aignan, France

来源：

ORGANIC LETTERS | 2002年 / 4卷 / 03期

关键词：

D O I：

10.1021/ol017011x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] he sodium salt of hypophosphorous acid is shown to act as a double radical precursor in a double, sequential radical addition on 3-exo-methylenefuranose derivative 14 and 4-ethylenefuranose 10 to furnish phosphinates 18d in good overall yields. Unambiguous structural assignment establishes the high diastereoselection of the process.

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页码：359 / 362

页数：4

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