Synthesis of novel 3′-methylene H-phosphonate thymidines

被引：9

作者：

An, HY ^{[1
]}

Wang, TM ^{[1
]}

Cook, PD ^{[1
]}

机构：

[1] ISIS Pharmaceut Inc, Carlsbad, CA 92008 USA

来源：

TETRAHEDRON LETTERS | 2000年 / 41卷 / 41期

关键词：

3 '-methylene; H-phosphonate; H-phosphonic acid; nucleotide; thymidine; Arbuzov reaction;

D O I：

10.1016/S0040-4039(00)01358-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of novel 5'-DMT- and 5'-MMT-protected 3'-methylene H-phosphonate thymidines 1-6, having methoxy, fluoro, hydrogen, and methoxyethoxy substituents at the 2'-position is reported. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：7813 / 7816

页数：4

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