Antivirals and resistance: influenza virus

被引：158

作者：

Ison, Michael G. ^{[1
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Div Infect Dis, Chicago, IL 60611 USA

来源：

CURRENT OPINION IN VIROLOGY | 2011年 / 1卷 / 06期

关键词：

SIALIDASE FUSION PROTEIN; CRITICALLY-ILL PATIENTS; ACTING NEURAMINIDASE INHIBITOR; A H1N1; INTRAVENOUS ZANAMIVIR; HOSPITALIZED-PATIENTS; OSELTAMIVIR RESISTANCE; TRANSPLANT RECIPIENTS; ADAMANTANE RESISTANCE; RESPIRATORY-FAILURE;

D O I：

10.1016/j.coviro.2011.09.002

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza causes annual epidemics of respiratory viral infections are associated with significant morbidity and mortality. Influenza vaccines have been shown to reduce the risk of infection and mitigate against some of the virus' sequellae. Likewise, two classes of antivirals, the adamantanes (amantadine and rimantadine) and the neuraminidase inhibitors (laninamivir, oseltamivir, peramivir, and zanamivir) are currently approved for the prevention and treatment of influenza; several other classes of antivirals and immune modulators are also currently under investigation. One of the greatest challenges to our armamentarium of antivirals is the emergence of resistant mutants. In this paper, we will review the currently approved and investigational antiviral agents and the mechanisms of resistance that impact their activity.

引用

页码：563 / 573

页数：11

共 111 条

[21] Severity of 2009 Pandemic Influenza A (H1N1) Virus Infection in Pregnant Women [J].

Creanga, Andreea A. ;

Johnson, Tamisha F. ;

Graitcer, Samuel B. ;

Hartman, Laura K. ;

Al-Samarrai, Teeb ;

Schwarz, Aviva G. ;

Chu, Susan Y. ;

Sackoff, Judith E. ;

Jamieson, Denise J. ;

Fine, Anne D. ;

Shapiro-Mendoza, Carrie K. ;

Jones, Lucretia E. ;

Uyeki, Timothy M. ;

Balter, Sharon ;

Bish, Connie L. ;

Finelli, Lyn ;

Honein, Margaret A. .

OBSTETRICS AND GYNECOLOGY, 2010, 115 (04) :717-726

[22] Surveillance of resistance to adamantanes among influenza A(H3N2) and A(H1N1) viruses isolated worldwide [J].

Deyde, Varough M. ;

Xu, Xiyan ;

Bright, Rick A. ;

Shaw, Michael ;

Smith, Catherine B. ;

Zhang, Ye ;

Shu, Yuelong ;

Gubareva, Larisa V. ;

Cox, Nancy J. ;

Klimov, Alexander I. .

JOURNAL OF INFECTIOUS DISEASES, 2007, 196 (02) :249-257

[23] Detection of Molecular Markers of Drug Resistance in 2009 Pandemic Influenza A (H1N1) Viruses by Pyrosequencing [J].

Deyde, Varough M. ;

Sheu, Tiffany G. ;

Trujillo, A. Angelica ;

Okomo-Adhiambo, Margaret ;

Garten, Rebecca ;

Klimov, Alexander I. ;

Gubareva, Larisa V. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (03) :1102-1110

[24] Comparison of elderly people's technique in using two dry powder inhalers to deliver zanamivir: randomised controlled trial [J].

Diggory, P ;

Fernandez, C ;

Humphrey, A ;

Jones, V ;

Murphy, M .

BRITISH MEDICAL JOURNAL, 2001, 322 (7286) :577-579

[25] Severe H1N1 Infection in a Pediatric Liver Transplant Recipient Treated With Intravenous Zanamivir: Efficiency and Complications [J].

Dohna-Schwake, Christian ;

Schweiger, Brunhilde ;

Felderhoff-Mueser, Ursula ;

Fiedler, Melanie ;

Kaiser, Gernot M. ;

Paul, Andreas ;

Gerner, Patrick ;

Lainka, Elke ;

Hoyer, Peter F. .

TRANSPLANTATION, 2010, 90 (02) :223-224

[26] Safety of Oseltamivir in Pregnancy A Review of Preclinical and Clinical Data [J].

Donner, Barbara ;

Niranjan, Viswanathan ;

Hoffmann, Gerhard .

DRUG SAFETY, 2010, 33 (08) :631-642

[27] Use of Intravenous Zanamivir after Development of Oseltamivir Resistance in a Critically Ill Immunosuppressed Child Infected with 2009 Pandemic Influenza A (H1N1) Virus [J].

Dulek, Daniel E. ;

Williams, John V. ;

Creech, C. Buddy ;

Schulert, Alynna K. ;

Frangoul, Haydar A. ;

Domm, Jennifer ;

Denison, Mark R. ;

Chappell, James D. .

CLINICAL INFECTIOUS DISEASES, 2010, 50 (11) :1493-1496

[28] Efficacy of Oseltamivir-Zanamivir Combination Compared to Each Monotherapy for Seasonal Influenza: A Randomized Placebo-Controlled Trial [J].

Duval, Xavier ;

van der Werf, Sylvie ;

Blanchon, Thierry ;

Mosnier, Anne ;

Bouscambert-Duchamp, Maude ;

Tibi, Annick ;

Enouf, Vincent ;

Charlois-Ou, Cecile ;

Vincent, Corine ;

Andreoletti, Laurent ;

Tubach, Florence ;

Lina, Bruno ;

Mentre, France ;

Leport, Catherine .

PLOS MEDICINE, 2010, 7 (11)

[29] Impact of rapid diagnosis on management of adults hospitalized with influenza [J].

Falsey, Ann R. ;

Murata, Yoshihiko ;

Walsh, Edward E. .

ARCHIVES OF INTERNAL MEDICINE, 2007, 167 (04) :E1-E7

[30]

Fine A., 2010, Morbidity and Mortality Weekly Report, V59, P321

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