FGF21 is an Akt-regulated myokine

被引：379

作者：

Izumiya, Yasuhiro ^{[1
]}

Bina, Holly A. ^{[2
]}

Ouchi, Noriyuki ^{[1
]}

Akasaki, Yuichi ^{[1
]}

Kharitonenkov, Alexei ^{[2
]}

Walsh, Kenneth ^{[1
]}

机构：

[1] Boston Univ, Sch Med, Whitaker Cardiovasc Inst, Boston, MA 02118 USA

[2] Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 27期

基金：

美国国家卫生研究院;

关键词：

FGF21; Akt; Metabolism; Transcript; Transgenic mice;

D O I：

10.1016/j.febslet.2008.10.021

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factor-21 (FGF21) functions as a metabolic regulator. The FGF21 transcript is reported to be abundantly expressed in liver, but little is known about the regulation of FGF21 expression in other tissues. In this study, we show that levels of FGF21 protein expression were similar in skeletal muscle and liver from fasted mice. FGF21 transcript and protein expression were upregulated in gastrocnemius muscle of skeletal muscle-specific Akt1 transgenic mice. Serum concentration of FGF21 was also increased by Akt1 transgene activation. In cultured skeletal muscle cells, FGF21 expression and secretion was regulated by insulin, Akt transduction and LY294002. These data indicate that skeletal muscle is a source of FGF21 and that its expression is regulated by a phosphatidylinosistol 3-kinase (PI3-kinase)/Akt1 signaling pathway-dependent mechanism. (C) 2008 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3805 / 3810

页数：6

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