FGF21 attenuates lipolysis in human adipocytes -: A possible link to improved insulin sensitivity

被引：196

作者：

Arner, Peter ^{[1
]}

Pettersson, Amanda ^{[1
]}

Mitchell, Pamela J. ^{[2
]}

Dunbar, James D. ^{[2
]}

Kharitonenkov, Alexei ^{[2
]}

Ryden, Mikael ^{[1
]}

机构：

[1] Karolinska Univ Hosp, Karolinska Inst M63, Dept Med, S-14186 Huddinge, Sweden

[2] Lilly Corp Ctr, Lilly Res Labs, BioTechnol Discovery Res, Indianapolis, IN 46285 USA

来源：

FEBS LETTERS | 2008年 / 582卷 / 12期

关键词：

adipocyte; lipolysis; differentiation; adipogenesis; perilipin; beta-klotho;

D O I：

10.1016/j.febslet.2008.04.038

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Fibroblast growth factor 21 (FGF21) is active in murine adipocytes and has beneficial metabolic effects in animal models of type 2 diabetes mellitus. We assessed whether FGF21 influences lipolysis in human adipocytes and 3T3-L1 cells. FGF21 had no short-time effect (h) while a 3-day incubation with FGF21 attenuated hormone-stimulated lipolysis. FGF21 did not influence the mRNA expression of genes involved in regulating lipolysis, but significantly reduced the expression of the lipid droplet-associated phosphoprotein perilipin without affecting differentiation. Via reduced release of fatty acids into the circulation, the anti-lipolytic effect could be a mechanism through which FGF21 promotes insulin sensitivity in man. (C) 2008 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：1725 / 1730

页数：6

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