Unraveling the genetic underpinnings of myeloproliferative neoplasms and understanding their effect on disease course and response to therapy: Proceedings from the 6th international post-ASH symposium

被引：15

作者：

Abdel-Wahab, Omar ^{[1
,2
]}

Pardanani, Animesh ^{[3
]}

Bernard, Olivier A. ^{[4
]}

Finazzi, Guido ^{[5
]}

Crispino, John D. ^{[6
]}

Gisslinger, Heinz

Kralovics, Robert ^{[7
]}

Odenike, Olatoyosi ^{[8
]}

Bhalla, Kapil ^{[9
]}

Gupta, Vikas ^{[10
]}

Barosi, Giovanni ^{[11
]}

Gotlib, Jason ^{[12
,13
,14
]}

Guglielmelli, Paola ^{[15
]}

Kiladjian, Jean-Jacques ^{[16
,17
]}

Noel, Pierre ^{[18
]}

Cazzola, Mario ^{[19
]}

Vannucchi, Alessandro M. ^{[15
]}

Hoffman, Ronald ^{[20
]}

Barbui, Tiziano ^{[5
]}

Thiele, Juergen ^{[21
]}

Van Etten, Richard A. ^{[22
]}

Mughal, Tariq ^{[7
]}

Tefferi, Ayalew ^{[3
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Leukemia Serv, New York, NY 10065 USA

[2] Mem Sloan Kettering Canc Ctr, Human Oncol & Pathogenesis Program, New York, NY 10065 USA

[3] Mayo Clin, Dept Internal Med, Div Hematol, Rochester, MN USA

[4] Inst Gustave Roussy, INSERM, U985, F-94805 Villejuif, France

[5] Osped Riuniti Bergamo, USC Hematol, Bergamo, Italy

[6] Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USA

[7] Med Univ Vienna, Dept Internal Med 1, Div Hematol & Blood Coagulat, Vienna, Austria

[8] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[9] Univ Kansas, Ctr Canc, Kansas City, KS USA

[10] Princess Margaret Hosp, Toronto, ON M4X 1K9, Canada

[11] IRCCS Policlin S Matteo Fdn, Ctr Study Myelofibrosis, Pavia, Italy

[12] Stanford Univ, Sch Med, Div Hematol, Stanford, CA 94305 USA

[13] Stanford Univ, Sch Med, Div Oncol, Stanford, CA 94305 USA

[14] Stanford Univ, Sch Med, Stanford Canc Ctr, Stanford, CA 94305 USA

[15] Univ Florence, Florence, Italy

[16] Hop St Louis, Ctr Invest Clin, Paris, France

[17] FIM French Intergrp Myeloproliferat Disorders, Paris, France

[18] Mayo Clin, Div Hematol & Med Oncol, Scottsdale, AZ USA

[19] Univ Pavia, Fdn IRCCS Policlin San Matteo, I-27100 Pavia, Italy

[20] Mt Sinai Sch Med, Myeloproliferat Disorders Res Consortium, Dept Med, Tisch Canc Inst, New York, NY USA

[21] Univ Cologne, D-50931 Cologne, Germany

[22] Tufts Med Ctr, Boston, MA USA

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2012年 / 87卷 / 05期

关键词：

HEMATOPOIETIC STEM-CELLS; CHRONIC MYELOMONOCYTIC LEUKEMIA; PRIMARY MYELOFIBROSIS; JAK2; INHIBITOR; CIRCULATING CD34(+); SELF-RENEWAL; TET2; MUTATIONS; EZH2; METHYLTRANSFERASE;

D O I：

10.1002/ajh.23169

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immediately after the annual scientific meeting of the American Society of Hematology (ASH), a select group of clinical and laboratory investigators in myeloproliferative neoplasms (MPN) is summoned to a post-ASH conference on chronic myeloid leukemia and the BCR-ABL1negative MPN. The 6th such meeting occurred on December 13-14, 2011, in La Jolla, California, USA, under the direction of its founder, Dr. Tariq Mughal. The current document is the first of two reports on this post-ASH event and summarizes the most recent preclinical and clinical advances in polycythemia vera, essential thrombocythemia, and primary myelofibrosis.

引用

页码：562 / 568

页数：7

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