Tumor environment: a potent driving force in colorectal cancer?

被引：39

作者：

Barker, N

Clevers, H

机构：

[1] Semaia Pharmaceut, NL-3584 CX Utrecht, Netherlands

[2] Univ Utrecht, Ctr Med, NL-3584 CX Utrecht, Netherlands

来源：

TRENDS IN MOLECULAR MEDICINE | 2001年 / 7卷 / 12期

关键词：

D O I：

10.1016/S1471-4914(01)02215-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Current models predict that colorectal carcinogenesis proceeds primarily through the progressive accumulation of fixed genetic changes in key tumor suppressor genes, oncogenes and DNA repair components. However, recent studies found evidence of dynamic changes in cellular adhesion and beta -catenin localization occurring during invasion, metastasis and expansion of well-differentiated colorectal cancers. It is proposed that such changes might be driven by the local tumor environment, which, if validated, would necessitate a revision of the current linear tumor progression model.

引用

页码：535 / 537

页数：3

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