Dopaminergic agents for the treatment of cocaine abuse

被引：47

作者：

Smith, MP

Hoepping, A

Johnson, KM

Trzcinska, M

Kozikowski, AP

机构：

[1] Georgetown Univ, Med Ctr, Drug Discovery Program, Washington, DC 20007 USA

[2] Univ Texas, Med Branch, Dept Pharmacol & Toxicol, Galveston, TX 77555 USA

[3] Northeastern Univ, Dept Psychol, Boston, MA 02115 USA

来源：

DRUG DISCOVERY TODAY | 1999年 / 4卷 / 07期

关键词：

D O I：

10.1016/S1359-6446(99)01332-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cocaine is a major drug of abuse whose devastating effects have captured the attention of health officials and policy makers. Based upon the alarming health and crime-related costs associated with the use of this powerful reinforcing drug, immediate therapies are needed for the treatment of cocaine addiction. In this review, some of the small-molecule-based approaches that have been pursued in the search for such medications are highlighted. Because the pharmacological actions of cocaine stem largely from its ability to block the dopamine transporter, many intervention strategies have focused on the dopaminergic pathway.

引用

收藏

页码：322 / 332

页数：11

相关论文

共 115 条

[31]

GIROS B, 1994, J BIOL CHEM, V269, P15985

[32] Mechanisms of antiaddictive actions of ibogaine [J].

Glick, SD ;

Maisonneuve, IM .

NEUROCHEMISTRY OF DRUGS OF ABUSE: COCAINE, IBOGAINE, AND SUBSTITUTED AMPHETAMINES, 1998, 844 :214-226

[33] EFFECTS OF IBOGA ALKALOIDS ON MORPHINE AND COCAINE SELF-ADMINISTRATION IN RATS - RELATIONSHIP TO TREMORIGENIC EFFECTS AND TO EFFECTS ON DOPAMINE RELEASE IN NUCLEUS-ACCUMBENS AND STRIATUM [J].

GLICK, SD ;

KUEHNE, ME ;

RAUCCI, J ;

WILSON, TE ;

LARSON, D ;

KELLER, RW ;

CARLSON, JN .

BRAIN RESEARCH, 1994, 657 (1-2) :14-22

[34] Effects of Dopamine Reuptake Inhibitors on Food- and Cocaine-Maintained Responding: I. Dependence on Unit Dose of Cocaine [J].

Glowa, John R. ;

Wojnicki, Francis H. E. ;

Matecka, Dorota ;

Bacher, John D. ;

Mansbach, Robert S. ;

Balster, Robert L. ;

Rice, Kenner C. .

EXPERIMENTAL AND CLINICAL PSYCHOPHARMACOLOGY, 1995, 3 (03) :219-231

[35] Novel pharmacotherapies for cocaine abuse - 1995 to present [J].

Glowa, JR ;

LeSage, M ;

Stafford, D ;

Vocci, F .

EXPERT OPINION ON THERAPEUTIC PATENTS, 1997, 7 (12) :1459-1476

[36] Sustained decrease in cocaine-maintained responding in rhesus monkeys with 1-[2-[bis(4-fluorophenyl)methoxy]ethyl]4-(3-hydroxy-3-phenylpropyl)piperazinyl decanoate, a long-acting ester derivative of GBR 12909 [J].

Glowa, JR ;

Fantegrossi, WE ;

Lewis, DB ;

Matecka, D ;

Rice, KC ;

Rothman, RB .

JOURNAL OF MEDICINAL CHEMISTRY, 1996, 39 (24) :4689-4691

[37]

Gorelick D A, 1998, Adv Pharmacol, V42, P995

[38] Replacement medication for cocaine dependence: Methylphenidate [J].

Grabowski, J ;

Roache, JD ;

Schmitz, JM ;

Rhoades, H ;

Creson, D ;

Korszun, A .

JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 1997, 17 (06) :485-488

[39] ABSENCE OF ACUTE COCAINE INTERACTIONS WITH THE MAO-B INHIBITOR SELEGILINE [J].

HABERNY, KA ;

WALSH, SL ;

GINN, DH ;

WILKINS, JN ;

GARNER, JE ;

SETODA, D ;

BIGELOW, GE .

DRUG AND ALCOHOL DEPENDENCE, 1995, 39 (01) :55-62

[40] Opioid reward mechanisms: a key role in drug abuse? [J].

Herz, A .

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY, 1998, 76 (03) :252-258

← 1 2 3 4 5 6 7 8 9 10 →