Developmental biology - Controlling the cellular brakes

被引：39

作者：

Carmeliet, P ^{[1
]}

机构：

[1] Katholieke Univ Leuven VIB, Ctr Transgene Technol & Gene Therapy, B-3000 Louvain, Belgium

来源：

NATURE | 1999年 / 401卷 / 6754期

关键词：

D O I：

10.1038/44304

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

How does a cell decide to become a nerve cell and not, say, an endothelial cell? Such cell-fate decisions are made by certain 'master' genes, which switch on cellular programmes to differentiate precursor cells into various cell types. Differentiation is thought to be kept in check by molecular 'brakes', and a study of mice lacking Id1 and Id3 indicates that these proteins could act as just such brakes.

引用

页码：657 / 658

页数：2

共 9 条

[1] THE PROTEIN ID - A NEGATIVE REGULATOR OF HELIX-LOOP-HELIX DNA-BINDING PROTEINS [J].

BENEZRA, R ;

DAVIS, RL ;

LOCKSHON, D ;

TURNER, DL ;

WEINTRAUB, H .

CELL, 1990, 61 (01) :49-59

[2] Role of HIF-1α or in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis [J].

Carmeliet, P ;

Dor, Y ;

Herbert, JM ;

Fukumura, D ;

Brusselmans, K ;

Dewerchin, M ;

Neeman, M ;

Bono, F ;

Abramovitch, R ;

Maxwell, P ;

Koch, CJ ;

Ratcliffe, P ;

Moons, L ;

Jain, RK ;

Collen, D ;

Keshet, E .

NATURE, 1998, 394 (6692) :485-490

[3] Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts [J].

Lyden, D ;

Young, AZ ;

Zagzag, D ;

Yan, W ;

Gerald, W ;

O'Reilly, R ;

Bader, BL ;

Hynes, RO ;

Zhuang, Y ;

Manova, K ;

Benezra, R .

NATURE, 1999, 401 (6754) :670-677

[4] Defining the regulatory networks for muscle development [J].

Molkentin, JD ;

Olson, EN .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1996, 6 (04) :445-453

[5] Id helix-loop-helix proteins in cell growth and differentiation [J].

Norton, JD ;

Deed, RW ;

Craggs, G ;

Sablitzky, F .

TRENDS IN CELL BIOLOGY, 1998, 8 (02) :58-65

[6] CLONING AND CHARACTERIZATION OF A BASIC HELIX-LOOP-HELIX PROTEIN EXPRESSED IN EARLY MESODERM AND THE DEVELOPING SOMITES [J].

QUERTERMOUS, EE ;

HIDAI, H ;

BLANAR, MA ;

QUERTERMOUS, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (15) :7066-7070

[7] Hypoxia-inducible factor 1:: master regulator of O2 homeostasis [J].

Semenza, GL .

CURRENT OPINION IN GENETICS & DEVELOPMENT, 1998, 8 (05) :588-594

[8]

Steingrímsson E, 1998, DEVELOPMENT, V125, P4607

[9] Unsuspected role for the T-cell leukemia protein SCL/tal-1 in vascular development [J].

Visvader, JE ;

Fujiwara, Y ;

Orkin, SH .

GENES & DEVELOPMENT, 1998, 12 (04) :473-479

← 1 →