Executive dysfunction in substance dependent individuals during drug use and abstinence:: An examination of the behavioral, cognitive and emotional correlates of addiction

被引:237
作者
Verdejo-Garcia, Antonio
Bechara, Antoine
Recknor, Emily C.
Perez-Garcia, Miguel
机构
[1] Univ Granada, Dept Personalidad Evaluac & Tratamiento Psicol, E-18071 Granada, Spain
[2] Univ Granada, Inst Neurosci Federico Oloriz, E-18071 Granada, Spain
[3] Univ So Calif, Inst Neurol Study Emot Decis Making & Creativ, Los Angeles, CA 90089 USA
[4] Univ Iowa, Dept Neurol, Iowa City, IA 52242 USA
关键词
apathy; disinhibition; executive dysfunction; dorsolateral prefrontal circuit; orbitofrontal prefrontal circuit; anterior cingulate circuit;
D O I
10.1017/S1355617706060486
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Increasing evidence indicates that substance-dependent individuals (SDI) are impaired in executive control tasks relying, on different systems within the prefrontal cortex (PFC). Three different functional systems have been described: the dorsolateral prefrontal cortex (DLPC), orbitofrontal cortex (OFC), and anterior cingulate Cortex (ACC) circuits. Dysfunction within each PFC system is associated with different behavioral, cognitive, and emotional abnormalities. Few Studies have conducted an exhaustive examination of all these different factors in SDI. In this Study, SDI (including alcohol, cocaine, Laid methamphetamine polysubstane users, n = 35) were compared with healthy controls (n = 36) on a series of behavioral (Frontal Systems Behaviour Scale, FrSBe), cognitive (N-back. Go-No Go, and Wisconsin Card Sorting Tasks), and emotional (International Affective Picture System. IAPS) tasks each of which was thought to tax a different component of these PFC functional systems. SDI showed greater behavioral problems in the apathy, disinhibition, and executive dysfunction subscales of the FrSBe. Behavioral deficits were significantly associated with several real-life domains in which SDI typically have problems. SDI also showed poorer performance on cognitive tests of working memory, response inhibition and mental flexibility. and abnormal processing of affective images front the LAPS. Cognitive, behavioral, and emotional measures were moderately correlated.
引用
收藏
页码:405 / 415
页数:11
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