Expression levels of vascular endothelial growth factor and its receptors in Parkinson's disease

被引：78

作者：

Wada, Keiichirou

Arai, Hiroyuki

Takanashi, Masashi

Fukae, Jiro

Oizumi, Hideki

Yasuda, Toru

Mizuno, Yoshikuni

Mochizuki, Hideki

机构：

[1] Juntendo Univ, Sch Med, Dept Neurol, Bunkyo Ku, Tokyo 1138421, Japan

[2] Juntendo Univ, Sch Med, Res Inst Dis Old Agr, Bunkyo Ku, Tokyo 1138421, Japan

来源：

NEUROREPORT | 2006年 / 17卷 / 07期

关键词：

angiogenesis; Flt-I neurogenesis; Flk-I; Parkinson's disease; vascular endothelial growth factor;

D O I：

10.1097/01.wnr.0000215769.71657.65

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Recently, we confirmed the presence of enhanced neural reconstruction in Parkinson's disease and in an animal model of Parkinson's disease based on increased polysialic acid-like immunoreactivity. Changes in neurogenesis often appear parallel to changes in angiogenesis. Moreover, both these processes share similar modulating factors, like vascular endothelial growth factor (VEGF) and its receptors VEGFR-I (Flt-1) and VEGFR-2 (Flk-1). Using immunohistochemistry, we identified in this study upregulation of VEGF in the substantia nigra but not in the striatum of patients with Parkinson's disease by enzyme-linked immunosorbent assay. Such overexpression may participate in vascular remodeling and neurogenesis in the substantia nigra of Parkinson's disease.

引用

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页码：705 / 709

页数：5

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