Lab-on-a-Chip Sensor with Evaporated Bismuth Film Electrode for Anodic Stripping Voltammetry of Zinc

被引：20

作者：

Kang, Wenjing ^{[1
]}

Pei, Xing ^{[1
]}

Yue, Wei ^{[2
]}

Bange, Adam ^{[3
]}

Heineman, William R. ^{[2
]}

Papautsky, Ian ^{[1
]}

机构：

[1] Univ Cincinnati, BioMicroSyst Lab, Dept Elect Engn & Comp Syst, Cincinnati, OH 45221 USA

[2] Univ Cincinnati, Dept Chem, Cincinnati, OH 45221 USA

[3] Xavier Univ, Dept Chem, Cincinnati, OH 45221 USA

来源：

ELECTROANALYSIS | 2013年 / 25卷 / 12期

基金：

美国国家卫生研究院;

关键词：

Anodic stripping voltammetry; Zinc; Lab-on-a-chip sensor; Dopamine; Evaporated Bi film electrode; TRACE-METALS; PERSISTENT DIARRHEA; HEAVY-METALS; SUPPLEMENTATION; BLOOD; CHILDREN; ZN; PB; METABOLISM; PLASMA;

D O I：

10.1002/elan.201300349

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

In this work, we report on the development of a lab-on-a-chip electrochemical sensor that uses an evaporated bismuth electrode to detect zinc using square wave anodic stripping voltammetry. The microscale electrochemical cell consists of a bismuth working electrode, an integrated silver/silver chloride reference electrode, and a gold auxiliary electrode. The sensor exhibits a linear response in 0.1M acetate buffer at pH6 with zinc concentrations in the 1-30M range and a calculated detection limit of 60nM. The sensor successfully detected zinc in a bovine serum extract and the results were corfirmed by independent AAS measurements. Our results demonstrate the advantageous qualities of this lab-on-a-chip electrochemical sensor for clinical applications, which include small sample volume (mu L scale), reduced cost, short response time and high accuracy at low concentrations of analyte.

引用

页码：2586 / 2594

页数：9

共 50 条

[21] Sonoelectroanalysis in acoustically emulsified media: Zinc and cadmium [J].

Kruusma, J ;

Tomcik, P ;

Banks, CE ;

Compton, RG .

ELECTROANALYSIS, 2004, 16 (10) :852-859

[22] Electroanalytical detection of zinc in whole blood [J].

Kruusma, J ;

Banks, CE ;

Nei, L ;

Compton, RG .

ANALYTICA CHIMICA ACTA, 2004, 510 (01) :85-90

[23] Differential pulse anodic stripping voltammetric determination of Pb, Cd, Cu, and Zn in air, diet, and blood samples: Exposure assessment [J].

Kumar, MP ;

Mouli, PC ;

Reddy, SJ ;

Mohan, SV .

ANALYTICAL LETTERS, 2005, 38 (03) :463-475

[24] Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response [J].

Liuzzi, JP ;

Lichten, LA ;

Rivera, S ;

Blanchard, RK ;

Aydemir, TB ;

Knutson, MD ;

Ganz, T ;

Cousins, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (19) :6843-6848

[25] Perfluorinated anion-exchange polymer mercury film electrode for anodic stripping voltammetric determination of zinc(II): effect of model organic compounds [J].

Lu, TH ;

Huang, JF ;

Sun, IW .

ANALYTICA CHIMICA ACTA, 2002, 454 (01) :93-100

[26] IN-FLOW SPECIATION OF COPPER, ZINC, LEAD AND CADMIUM IN FRESH-WATERS BY SQUARE-WAVE ANODIC-STRIPPING VOLTAMMETRY .2. OPTIMIZATION OF MEASUREMENT STEP [J].

MARTINOTTI, W ;

QUEIRAZZA, G ;

GUARINONI, A ;

MORI, G .

ANALYTICA CHIMICA ACTA, 1995, 305 (1-3) :183-191

[27]

Morrison G., 1990, Clinical Methods: The History, Physical, and Laboratory Examinations

[28] Disposable electrochemical flow cells for catalytic adsorptive stripping voltammetry (CAdSV) at a bismuth film electrode (BiFE) [J].

Naseri, Nahid Gharib ;

Baldock, Sara J. ;

Economou, Anastasios ;

Goddard, Nicholas J. ;

Fielden, Peter R. .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2008, 391 (04) :1283-1292

[29] An unusual source of excess zinc, leading to hypocupremia and neurologic disease [J].

Nations, S. P. ;

Boyer, P. J. ;

Love, L. A. ;

Burritt, M. F. ;

Butz, J. A. ;

Wolfe, G. I. ;

Hynan, L. S. ;

Reisch, J. ;

Trivedi, J. R. .

NEUROLOGY, 2008, 71 (09) :639-643

[30] ANODIC STRIPPING VOLTAMMETRY OF NICKEL AT SOLID ELECTRODES [J].

NICHOLSON, MM .

ANALYTICAL CHEMISTRY, 1960, 32 (09) :1058-1062

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