A Neurogenetic Approach to Impulsivity

被引:118
作者
Congdon, Eliza [1 ]
Canli, Turhan [1 ]
机构
[1] SUNY Stony Brook, Dept Psychol, Grad Program Genet, Stony Brook, NY 11794 USA
关键词
D O I
10.1111/j.1467-6494.2008.00528.x
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Impulsivity is a complex and multidimensional trait that is of interest to both personality psychologists and to clinicians. For investigators seeking the biological basis of personality traits, the use of neuroimaging techniques such as positron emission tomography (PET) and functional magnetic resonance imaging (fMRI) revolutionized personality psychology in less than a decade. Now, another revolution is under way, and it originates from molecular biology. Specifically, new findings in molecular genetics, the detailed mapping and the study of the function of genes, have shown that individual differences in personality traits can be related to individual differences within specific genes. In this article, we will review the current state of the field with respect to the neural and genetic basis of trait impulsivity.
引用
收藏
页码:1447 / 1483
页数:37
相关论文
共 192 条
[31]   Global and regional gray matter reductions in ADHD:: A voxel-based morphometric study [J].
Carmona, S ;
Vilarroya, O ;
Bielsa, A ;
Trèmols, V ;
Soliva, JC ;
Rovira, M ;
Tomàs, J ;
Raheb, C ;
Gispert, JD ;
Batlle, S ;
Bulbena, A .
NEUROSCIENCE LETTERS, 2005, 389 (02) :88-93
[32]   Genotypic interaction between DRD4 and DAT1 loci is a high risk factor for attention-deficit/hyperactivity disorder in Chilean families [J].
Carrasco, X ;
Rothhammer, P ;
Moraga, M ;
Henríquez, H ;
Chakraborty, R ;
Aboitiz, F ;
Rothhammer, F .
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (01) :51-54
[33]   Relations of serotonin function to personality: Current views and a key methodological issue [J].
Carver, Charles S. ;
Miller, Christopher J. .
PSYCHIATRY RESEARCH, 2006, 144 (01) :1-15
[34]   A developmental functional MRI study of prefrontal activation during performance of a Go-No-Go task [J].
Casey, BJ ;
Trainor, RJ ;
Orendi, JL ;
Schubert, AB ;
Nystrom, LE ;
Giedd, JN ;
Castellanos, FX ;
Haxby, JV ;
Noll, DC ;
Cohen, JD ;
Forman, SD ;
Dahl, RE ;
Rapoport, JL .
JOURNAL OF COGNITIVE NEUROSCIENCE, 1997, 9 (06) :835-847
[35]   Implication of right frontostriatal circuitry in response inhibition and attention-deficit/hyperactivity disorder [J].
Casey, BJ ;
Castellanos, FX ;
Giedd, JN ;
Marsh, WL ;
Hamburger, SD ;
Schubert, AB ;
Vauss, YC ;
Vaituzis, AC ;
Dickstein, DP ;
Sarfatti, SE ;
Rapoport, JL .
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY, 1997, 36 (03) :374-383
[36]   Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes [J].
Castellanos, FX ;
Tannock, R .
NATURE REVIEWS NEUROSCIENCE, 2002, 3 (08) :617-628
[37]   Executive "brake failure" following deactivation of human frontal lobe [J].
Chambers, CD ;
Bellgrove, MA ;
Stokes, MG ;
Henderson, TR ;
Garavan, H ;
Robertson, IH ;
Morris, AP ;
Mattingley, JB .
JOURNAL OF COGNITIVE NEUROSCIENCE, 2006, 18 (03) :444-455
[38]   Functional analysis of genetic variation in catechol-o-methyltransferase (COMT):: Effects on mRNA, protein, and enzyme activity in postmortem human brain [J].
Chen, JS ;
Lipska, BK ;
Halim, N ;
Ma, QD ;
Matsumoto, M ;
Melhem, S ;
Kolachana, BS ;
Hyde, TM ;
Herman, MM ;
Apud, J ;
Egan, MF ;
Kleinman, JE ;
Weinberger, DR .
AMERICAN JOURNAL OF HUMAN GENETICS, 2004, 75 (05) :807-821
[39]   A PSYCHOBIOLOGICAL MODEL OF TEMPERAMENT AND CHARACTER [J].
CLONINGER, CR ;
SVRAKIC, DM ;
PRZYBECK, TR .
ARCHIVES OF GENERAL PSYCHIATRY, 1993, 50 (12) :975-990
[40]  
Congdon Eliza, 2005, Behav Cogn Neurosci Rev, V4, P262, DOI 10.1177/1534582305285980