Microprobe X-ray absorption spectroscopic determination of the oxidation state of intracellular chromium following exposure of V79 Chinese hamster lung cells to genotoxic chromium complexes

被引：44

作者：

Dillon, CT

Lay, PA

Cholewa, M

Legge, GJF

Bonin, AM

Collins, TJ

Kostka, KL

SheaMcCarthy, G

机构：

[1] UNIV SYDNEY, SCH CHEM, SYDNEY, NSW 2006, AUSTRALIA

[2] UNIV MELBOURNE, SCH PHYS, MICRO ANALYT RES CTR, PARKVILLE, VIC 3052, AUSTRALIA

[3] INST NUCL PHYS, KRAKOW, POLAND

[4] WORKSAFE AUSTRALIA, SYDNEY, NSW 2001, AUSTRALIA

[5] CARNEGIE MELLON UNIV, DEPT CHEM, PITTSBURGH, PA 15213 USA

[6] UNIV CHICAGO, CARS, NATL SYNCHROTRON LIGHT SOURCE DEPT, BROOKHAVEN NATL LAB, UPTON, NY 11973 USA

来源：

CHEMICAL RESEARCH IN TOXICOLOGY | 1997年 / 10卷 / 05期

关键词：

D O I：

10.1021/tx970010m

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The oxidation state of intracellular chromium has been determined directly in mammalian lung cells exposed to mutagenic and carcinogenic chromium compounds. Microprobe X-ray absorption spectroscopy (XAS) experiments on single V79 Chinese hamster lung cells showed that Cr(VI) and Cr(V) complexes were reduced completely (>90%) to Cr(III) within 4 h of exposure of the cells. This result provides direct evidence for the hypothesis that these genotoxic oxidants react rapidly with intracellular reductants.

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页码：533 / 535

页数：3

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