A 500-kb physical map and contig from the Harvey ras-1 gene to the 11p telomere

被引：10

作者：

Russell, MW

Munroe, DJ

Bric, E

Housman, DE

DietzBand, J

Riethman, HC

Collins, FS

Brody, LC

机构：

[1] NIH,NATL CTR HUMAN GENOME RES,LAB GENE TRANSFER,BETHESDA,MD 20892

[2] UNIV MICHIGAN,DEPT PEDIAT & COMMUNICABLE DIS,ANN ARBOR,MI 48109

[3] UNIV MICHIGAN,DIV HUMAN GENET,ANN ARBOR,MI 48109

[4] UNIV MICHIGAN,DEPT INTERNAL MED,ANN ARBOR,MI 48109

[5] MIT,CTR CANC RES,CAMBRIDGE,MA 02139

[6] ONCOR INC,DEPT RES & DEV,GAITHERSBURG,MD 20877

[7] WISTAR INST ANAT & BIOL,PHILADELPHIA,PA 19104

来源：

GENOMICS | 1996年 / 35卷 / 02期

关键词：

D O I：

10.1006/geno.1996.0367

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

A contiguous physical map was constructed from the Harvey ras-l (HRAS1) gene to the lip telomere. The contig spans approximately 500 kb and is minimally composed of a telomere-containing YAC and P1 and cosmid clones. Included in the contig are 11 sequence-tagged sites derived from P1 and cosmid ends. Three genes were placed on the contig in the following order: telomere-ribonuclease/angiogenin inhibitor (RNH)-Harvey ras-1 (HRAS1)-HRAS1-related complex (HRC). Two novel tetranucleotide repeats (heterozygosity of 66 and 68%) and a complex CA repeat (heterozygosity of 78%) were isolated and characterized. (C) 1996 Academic Press, Inc.

引用

页码：353 / 360

页数：8

共 33 条

[1] 3 TUMOR-SUPPRESSOR REGIONS ON CHROMOSOME-11P IDENTIFIED BY HIGH-RESOLUTION DELETION MAPPING IN HUMAN NON-SMALL-CELL LUNG-CANCER [J].