Developing functional magnetic resonance imaging techniques for alert macaque monkeys

被引：21

作者：

Gamlin, PD ^{[1
]}

Ward, MK ^{[1
]}

Bolding, MS ^{[1
]}

Grossmann, JK ^{[1
]}

Twieg, DB ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Vis Sci, Dept Biomed Engn, Ctr Dev Funct Imaging, Birmingham, AL 35294 USA

来源：

METHODS | 2006年 / 38卷 / 03期

关键词：

BOLD; vertical MRI; physiological noise; behavior;

D O I：

10.1016/j.ymeth.2005.08.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Functional magnetic resonance imaging (fMRI) has developed rapidly into a major non-invasive tool for studying the human brain. However, due to a variety of technical difficulties, it has yet to be widely adopted for use in alert, trained non-human primates. Our laboratory has been developing techniques for such fMRI studies. As background, we first consider basic principles of fMRI imaging, experimental design, and post-processing. We discuss appropriate MRI system hardware and components for conducting fMRI studies in alert macaques, and the animal preparation and behavior necessary for optimal experiments. Finally, we consider alternative fMRI techniques using exogenous contrast agents, arterial spin labeling, and more direct measures of neural activation. (c) 2006 Elsevier Inc. All rights reserved.

引用

页码：210 / 220

页数：11

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[41] ULTRAFAST INTERLEAVED GRADIENT-ECHO-PLANAR IMAGING ON A STANDARD SCANNER [J].