Kinetic resolution of amino alcohol derivatives with a chiral nucleophilic catalyst:: access to enantiopure cyclic cis-amino alcohols

被引：84

作者：

Kawabata, T ^{[1
]}

Yamamoto, K ^{[1
]}

Momose, Y ^{[1
]}

Yoshida, H ^{[1
]}

Nagaoka, Y ^{[1
]}

Fuji, K ^{[1
]}

机构：

[1] Kyoto Univ, Inst Chem Res, Kyoto 6110011, Japan

来源：

CHEMICAL COMMUNICATIONS | 2001年 / 24期

关键词：

D O I：

10.1039/b108753c

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Acylative kinetic resolution of racemic cyclic cis-amino alcohol derivatives with a chiral nucleophilic catalyst proceeds enantioselectively (s = 10-21) at ambient temperature to give enantiopure recovered materials, and the % conversion of the acylation can be readily controlled by the amount of acid anhydride.

引用

页码：2700 / 2701

页数：2

共 23 条

[1]

Arai S, 2001, ANGEW CHEM INT EDIT, V40, P234, DOI 10.1002/1521-3773(20010105)40:1<234::AID-ANIE234>3.0.CO

[2]

2-K

[3] HIGHLY DIASTEREOSELECTIVE DIELS-ALDER REACTION MEDIATED BY A CHIRAL AUXILIARY DERIVED FROM AMINO INDANOL - THE ROLE OF CONFORMATION ON DIASTEREOSELECTIVITY [J].