Herpes virus infections occur frequently following treatment with fludarabine: results of a prospective natural history study

被引：29

作者：

Byrd, JC

McGrail, LH

Hospenthal, DR

Howard, RS

Dow, NA

Diehl, LF

机构：

[1] Walter Reed Army Med Ctr, Hematol Oncol Serv, Washington, DC 20307 USA

[2] Walter Reed Army Med Ctr, Infect Dis Serv, Washington, DC 20307 USA

[3] Uniformed Serv Univ Hlth Sci, Washington, DC USA

[4] Uniformed Serv Univ Hlth Sci, Bethesda, MD 20814 USA

[5] Walter Reed Army Med Ctr, Dept Clin Invest, Washington, DC 20307 USA

[6] Walter Reed Army Med Ctr, Dept Pathol, Washington, DC 20307 USA

[7] Johns Hopkins Univ, Sch Med, Johns Hopkins Oncol Ctr, Div Hematol Malignancies, Baltimore, MD 21205 USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1999年 / 105卷 / 02期

关键词：

chronic lymphocytic leukaemia; non-Hodgkin's lymphoma; varicella zoster; herpes simplex; fludarabine;

D O I：

10.1111/j.1365-2141.1999.01364.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We performed a prospective infectious natural history study of 21 patients with low-grade lymphoproliferative disorders receiving fludarabine as initial (n=5) or salvage (n = 16) therapy 12 (57%) of these patients developed herpes tester (n = 9), herpes simplex I (n = 1) or herpes simplex II (n = 2) infections at a median of 8 (range 1-17) months following initiation of fludarabine, with 75% of these having completed therapy. AU patients with herpes tester developed severe post-herpetic neuralgia, Factors differentiating patients developing these infections included older age and low serum IgG or IgA. Based upon these prospective data, we conclude that herpes virus infections frequently occur following fludarabine treatment, necessitating aggressive patient education and new prophylactic strategies.

引用

页码：445 / 447

页数：3

共 12 条

[1] IMMUNOSUPPRESSIVE EFFECTS AND CLINICAL-RESPONSE OF FLUDARABINE IN REFRACTORY CHRONIC LYMPHOCYTIC-LEUKEMIA [J].