Interference of the galactose-dependent binding of lectins by novel pentapeptide ligands

被引：31

作者：

Arnusch, CJ

André, S

Valentini, P

Lensch, M

Russwurm, R

Siebert, HC

Fischer, MJE

Gabius, HJ

Pieters, RJ

机构：

[1] Univ Utrecht, Utrecht Inst Pharmaceut Sci, Dept Med Chem, NL-3508 TB Utrecht, Netherlands

[2] Univ Munich, Tierarztliche Fak, Inst Physiol Chem, D-80539 Munich, Germany

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2004年 / 14卷 / 06期

关键词：

D O I：

10.1016/j.bmcl.2004.01.029

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A library of pentapeptides containing the sequence -Y X-Y- based on rational design was screened with six different lectins. Sequences were identified that modulate galectin binding to its natural carbohydrate ligand. SPR showed inhibition values 2-3 times stronger than galactose and NMR studies suggested real carbohydrate mimicry. (C) 2004 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1437 / 1440

页数：4

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