Gene expression profiling of lymphoid malignancies

被引:86
作者
Staudt, LM [1 ]
机构
[1] NCI, Metab Branch, Ctr Canc Res, Bethesda, MD 20892 USA
来源
ANNUAL REVIEW OF MEDICINE | 2002年 / 53卷
关键词
genomics; microarray; lymphoma; leukemia; BCL-6;
D O I
10.1146/annurev.med.53.082901.103941
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Comprehensive gene expression profiling using DNA microarrays is providing a molecular classification of cancer into disease categories that are homogeneous with respect to pathogenesis and clinical behavior. Gene expression profiling revealed that diffuse large B cell lymphoma (DLBCL) consists of at least two molecularly distinct diseases that are derived from distinct stages of B cell differentiation and have strikingly different clinical outcomes. By contrast, chronic lymphocytic leukemia (CLL) was found to be a single disease defined by a characteristic gene expression signature. Nonetheless, gene expression profiling distinguished two clinically divergent CLL subtypes and provided evidence that signaling through the B cell antigen receptor may play a role in the clinically aggressive subtype. Gene expression analysis also illuminated the mechanism of lymphomagenesis caused by BCL-6 translocations and provided evidence that the NF-kappaB signaling pathway is a new molecular therapeutic target in DLBCL.
引用
收藏
页码:303 / 318
页数:18
相关论文
共 59 条
  • [11] CHRONIC LYMPHOCYTIC LEUKEMIC (CLL) CELLS SECRETE MULTISPECIFIC AUTOANTIBODIES
    BROKER, BM
    KLAJMAN, A
    YOUINOU, P
    JOUQUAN, J
    WORMAN, CP
    MURPHY, J
    MACKENZIE, L
    QUARTEYPAPAFIO, R
    BLASCHEK, M
    COLLINS, P
    LAL, S
    LYDYARD, PM
    [J]. JOURNAL OF AUTOIMMUNITY, 1988, 1 (05) : 469 - 481
  • [12] DNA double-strand breaks in immunoglobulin genes undergoing somatic hypermutation
    Bross, L
    Fukita, Y
    McBlane, F
    Démollière, C
    Rajewsky, K
    Jacobs, H
    [J]. IMMUNITY, 2000, 13 (05) : 589 - 597
  • [13] BCL-6 PROTEIN IS EXPRESSED IN GERMINAL-CENTER B-CELLS
    CATTORETTI, G
    CHANG, CC
    CECHOVA, K
    ZHANG, JD
    YE, BH
    FALINI, B
    LOUIE, DC
    OFFIT, K
    CHAGANTI, RSK
    DALLAFAVERA, R
    [J]. BLOOD, 1995, 86 (01) : 45 - 53
  • [14] Chan WC, 1997, BLOOD, V89, P3909
  • [15] BCL-6, a POZ/zinc-finger protein, is a sequence-specific transcriptional repressor
    Chang, CC
    Ye, BH
    Chaganti, RSK
    DallaFavera, R
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (14) : 6947 - 6952
  • [16] Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia
    Damle, RN
    Wasil, T
    Fais, F
    Ghiotto, F
    Valetto, A
    Allen, SL
    Buchbinder, A
    Budman, D
    Dittmar, K
    Kolitz, J
    Lichtman, SM
    Schulman, P
    Vinciguerra, VP
    Rai, KR
    Ferrarini, M
    Chiorazzi, N
    [J]. BLOOD, 1999, 94 (06) : 1840 - 1847
  • [17] DAVIS RE, 2001, UNPUB CONSTITUTIVE N
  • [18] Control of inflammation, cytokine expression, and germinal center formation by BCL-6
    Dent, AL
    Shaffer, AL
    Yu, X
    Allman, D
    Staudt, LM
    [J]. SCIENCE, 1997, 276 (5312) : 589 - 592
  • [19] DEWEINDT C, 1995, CELL GROWTH DIFFER, V6, P1495
  • [20] Cluster analysis and display of genome-wide expression patterns
    Eisen, MB
    Spellman, PT
    Brown, PO
    Botstein, D
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (25) : 14863 - 14868