A new solid-phase support for oligonucleotide synthesis

被引：6

作者：

Devivar, RV ^{[1
]}

Koontz, SL ^{[1
]}

Peltier, WJ ^{[1
]}

Pearson, JE ^{[1
]}

Guillory, TA ^{[1
]}

Fabricant, JD ^{[1
]}

机构：

[1] FlowGenix Corp, Webster, TX 77598 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 09期

关键词：

D O I：

10.1016/S0960-894X(99)00177-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

An alternative solid support for oligonucleotide synthesis was developed by coupling a polymer colloid to a modified polyethylene filter disc. The functions on the polymer colloid not used for attachment to the surface were derivatized with a Jeffamine(R) diamine and loaded with appropriate deoxynucleoside succinates. The performance of this support system was evaluated and compared to existing resins. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：1239 / 1242

页数：4

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