A new paradigm for biohydroxylation by Beauveria bassiana ATCC 7159

被引：50

作者：

Holland, HL ^{[1
]}

Morris, TA ^{[1
]}

Nava, PJ ^{[1
]}

Zabic, M ^{[1
]}

机构：

[1] Brock Univ, Dept Chem, St Catharines, ON L2S 3A1, Canada

来源：

TETRAHEDRON | 1999年 / 55卷 / 24期

关键词：

amides; enzymes and enzyme reactions; fungi; hydroxylation;

D O I：

10.1016/S0040-4020(99)00393-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The biohydroxylation of a series of amides and related amino, keto and hydrocarbon substrates by the fungal biocatalyst Beauveria bassiana ATCC 7159 has been examined. The product distributions, together with data obtained from selective inhibition experiments using the cyt.P-450 inhibitors isosafrole, 1-aminobenzotriazole and phenylacetylene, suggest that B. bassiana contains a range of hydroxylase enzymes with different substrate specificities. A paradigm is presented for the interpretation of the results of microbial hydroxylation and for the application of existing active site models for B. bassiana. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：7441 / 7460

页数：20

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