Biohydroxylations of Cbz-protected alkyl substituted piperidines by Beauveria bassiana ATCC 7159

被引：18

作者：

Aitken, SJ ^{[1
]}

Grogan, G ^{[1
]}

Chow, CSY ^{[1
]}

Turner, NJ ^{[1
]}

Flitsch, SL ^{[1
]}

机构：

[1] Univ Edinburgh, Dept Chem, Ctr Prot Technol, Edinburgh EH9 3JJ, Midlothian, Scotland

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1998年 / 20期

关键词：

D O I：

10.1039/a805800h

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-Benzyloxycarbonyl (Cbz) protected piperidines are hydroxylated with greater regioselectivity than the corresponding N-benzoyl analogues when incubated with the fungus Beauveria bassiana ATCC 7159. Cbz-protected piperidines 1-3, 5-7, have been biotransformed by growing cell suspensions of this fungus to yield predominantly 4-hydroxylated products in up to 48% yield. The regiospecificity of hydroxylation was only compromised significantly with N-Cbz-3-methylpiperidine 3 and N-Cbz-2-methylpiperidine 4 where hydroxylation occurred in both the 3 and 4 positions.

引用

页码：3365 / 3370

页数：6

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