Microbial hydroxylation of 2-cycloalkylbenzoxazoles .2. Determination of product structures and enhancement of enantiomeric excess

被引：19

作者：

deRaadt, A ^{[1
]}

Griengl, H ^{[1
]}

Petsch, M ^{[1
]}

Plachota, P ^{[1
]}

Schoo, N ^{[1
]}

Weber, H ^{[1
]}

Braunegg, G ^{[1
]}

Kopper, I ^{[1
]}

Kreiner, M ^{[1
]}

Zeiser, K ^{[1
]}

机构：

[1] GRAZ TECH UNIV,INST BIOTECHNOL,A-8010 GRAZ,AUSTRIA

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1016/0957-4166(96)00031-6

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The determinations of product structures obtained in the microbial hydroxylations of various 2-cycloalkyl-1, 3-benzoxazoles using Cunninghamella blakesleeana DSM 1906 and Bacillus megaterium DSM 32 are described. The initially low e.e. of 3-(benz-1, 3-oxazol-2-yl)cyclopentan-1-ol 6, 2-(benz-1, 3-oxazol-2-yl)cyclohexan-1-ol 14 and 4-(2-bent-1, 3-oxazol-2-yl)cycloheptan-1-ol 21 can be enhanced to 98% using lipase catalyzed resolution.

引用

页码：473 / 490

页数：18

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