Use of magnetic nanoparticles as nanosensors to probe for molecular interactions

被引：205

作者：

Perez, JM ^{[1
]}

Josephson, L ^{[1
]}

Weissleder, R ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Massachusetts Gen Hosp, Ctr Mol Imaging Res, Charlestown, MA 02129 USA

来源：

CHEMBIOCHEM | 2004年 / 5卷 / 03期

关键词：

magnetic resonance imaging; molecular recognition; nanosensors; nanostructures; NMR spectroscopy;

D O I：

10.1002/cbic.200300730

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Biocompatible magnetic nanosensors have been designed to detect molecular interactions in biological media. Upon target binding, these nanosensors cause changes in the spin-spin relaxation times of neighboring water molecules, which con be detected by magnetic resonance (NMR/MRI) techniques. These magnetic nanosensors have been designed to detect specific mRNA, proteins, enzymatic activity, and pathogens (e.g., virus) with sensitivity in the low femtomole range (0.5 - 30 fmol).

引用

页码：261 / 264

页数：4

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