Advanced glycosylation end products stimulate the growth but inhibit the prostacyclin-producing ability of endothelial cells through interactions with their receptors

被引：64

作者：

Yamagishi, S

Yamamoto, Y

Harada, S

Hsu, CC

Yamamoto, H

机构：

[1] KANAZAWA UNIV,SCH MED,DEPT BIOCHEM,KANAZAWA,ISHIKAWA 920,JAPAN

[2] KANAZAWA UNIV,SCH MED,DEPT INTERNAL MED 1,KANAZAWA,ISHIKAWA 920,JAPAN

[3] CHUNG SHAN MED & DENT COLL,TAICHUNG,TAIWAN

来源：

FEBS LETTERS | 1996年 / 384卷 / 01期

关键词：

advanced glycosylation end products (AGE); receptor for AGE (RAGE); antisense oligodeoxyribonucleotide; endothelial cell; pericyte; diabetic angiopathy;

D O I：

10.1016/0014-5793(96)00279-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The influence of advanced glycosylation end products (AGE) on endothelial cells was investigated. When human umbilical endothelial cells were cultured with AGE-bovine serum albumin, viable cell number as well as DNA synthesis was significantly stimlulated, whereas prostacyclin production by the endothelial cells was decreased. Antisense oligodeoxyribonucleotides against mRNA coding for AGE receptor mere found to reverse both the AGE-induced growth stimulation and the inhibition of prostacyclin production in endothelial cells. These results thus suggest that AGE ligand-receptor interactions in endothelial cells can promote angiogenesis and thrombogenesis, leading to the development of diabetic vascular complications.

引用

页码：103 / 106

页数：4

共 13 条

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