Integration of enabling methods for the automated flow preparation of piperazine-2-carboxamide

被引：52

作者：

Ingham, Richard J. ^{[1
]}

Battilocchio, Claudio ^{[1
]}

Hawkins, Joel M. ^{[2
]}

Ley, Steven V. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Chem, Innovat Technol Ctr, Cambridge CB2 1EW, England

[2] Pfizer Worldwide Res & Dev, Groton, CT 06340 USA

来源：

BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY | 2014年 / 10卷

关键词：

automation; flow chemistry; hydration; hydrogenation; sustainable processing; SUPER-MODIFIED SIMPLEX; ORGANIC-SYNTHESIS; OPTIMIZATION; EFFICIENT; SYSTEM; TECHNOLOGY; CHEMISTRY; HYDRATION; NITRILES; ZIRCONIA;

D O I：

10.3762/bjoc.10.56

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Here we describe the use of a new open-source software package and a Raspberry Pi (R) computer for the simultaneous control of multiple flow chemistry devices and its application to a machine-assisted, multi-step flow preparation of pyrazine-2-carboxamide - a component of Rifater (R), used in the treatment of tuberculosis - and its reduced derivative piperazine-2-carboxamide.

引用

页码：641 / 652

页数：12

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