Survey of GMP bulk reactions run in a research facility between 1985 and 2002

被引：273

作者：

Dugger, RW ^{[1
]}

Ragan, JA ^{[1
]}

Ripin, DHB ^{[1
]}

机构：

[1] Pfizer Inc, Pfizer Global Res Div, Groton, CT 06340 USA

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2005年 / 9卷 / 03期

关键词：

D O I：

10.1021/op050021j

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A review of reactions scaled in the GMP facilities at the Pfizer-Groton site was undertaken. Reactions were categorized into one of seven categories: carbon-carbon bond formation, carboxylic acid derivative interconversion, carbon-nitrogen bond formation, carbon-oxygen bond formation, red-ox, salt formation/resolution, and other. Reactions scaled from 1997 to 2002 were compared to chemistry scaled from 1985 to 1996 to look for changes in the nature of chemistry being scaled between the two time periods. Reactions were further subcategorized within those categories, and some interesting trends were noted.

引用

页码：253 / 258

页数：6

共 11 条

[1]

Ende DJA, 1998, ORG PROCESS RES DEV, V2, P382

[2] SYNTHESIS OF THE C-10-C-34 SEGMENT OF THE IMMUNOSUPPRESSANT FK506 [J].

GU, RL ;

SIH, CJ .

TETRAHEDRON LETTERS, 1990, 31 (23) :3287-3290

[3] Total synthesis of (-)-reserpine using the chiron approach [J].

Hanessian, S ;

Pan, JW ;

Carnell, A ;

Bouchard, H ;

Lesage, L .

JOURNAL OF ORGANIC CHEMISTRY, 1997, 62 (03) :465-473

[4] A total synthesis of FK-506 [J].

Ireland, RE ;

Gleason, JL ;

Gegnas, LD ;

Highsmith, TK .

JOURNAL OF ORGANIC CHEMISTRY, 1996, 61 (20) :6856-6872

[5] A FORMAL SYNTHESIS OF FK-506 - EXPLORATION OF SOME ALTERNATIVES TO MACROLACTAMIZATION [J].

JONES, AB ;

VILLALOBOS, A ;

LINDE, RG ;

DANISHEFSKY, SJ .

JOURNAL OF ORGANIC CHEMISTRY, 1990, 55 (09) :2786-2797

[6] CHEMISTRY OF TRICARBONYL HEMIKETALS AND APPLICATION OF EVANS TECHNOLOGY TO THE TOTAL SYNTHESIS OF THE IMMUNOSUPPRESSANT (-)-FK-506 [J].

JONES, TK ;

REAMER, RA ;

DESMOND, R ;

MILLS, SG .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (08) :2998-3017

[7] GENERAL STRATEGIES FOR THE SYNTHESIS OF INDOLE ALKALOIDS - TOTAL SYNTHESES OF (+/-)-RESERPINE AND (+/-)-ALPHA-YOHIMBINE [J].

MARTIN, SF ;

RUEGER, H ;

WILLIAMSON, SA ;

GRZEJSZCZAK, S .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1987, 109 (20) :6124-6134

[8] TOTAL SYNTHESIS OF FK506 AND AN FKBP PROBE REAGENT, (C8,C9-(C-13)2)-FK506 [J].

NAKATSUKA, M ;

RAGAN, JA ;

SAMMAKIA, T ;

SMITH, DB ;

UEHLING, DE ;

SCHREIBER, SL .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1990, 112 (14) :5583-5601

[9] TOTAL SYNTHESIS OF RESERPINE [J].

PEARLMAN, BA .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1979, 101 (21) :6404-6408

[10] FORMAL TOTAL SYNTHESIS OF FK506 - CONCISE CONSTRUCTION OF THE C(10)-C(34) SEGMENT VIA AN EFFECTIVE COUPLING TACTIC [J].

SMITH, AB ;

CHEN, KM ;

ROBINSON, DJ ;

LAAKSO, LM ;

HALE, KJ .

TETRAHEDRON LETTERS, 1994, 35 (25) :4271-4274

← 1 2 →