Immunomodulatory functions of type I interferons

被引：797

作者：

Gonzalez-Navajas, Jose M. ^{[1
,2
,3
]}

Lee, Jongdae ^{[1
]}

David, Michael ^{[4
]}

Raz, Eyal ^{[1
]}

机构：

[1] Univ Calif San Diego, Dept Med, Div Rheumatol Allergy & Immunol, La Jolla, CA 92093 USA

[2] Inst Salud Carlos III, Biomed Res Ctr Hepat & Digest Dis CIBERehd, Madrid, Spain

[3] Hosp Gen Alicante, Fdn Invest, Alicante, Spain

[4] Univ Calif San Diego, Div Biol Sci, La Jolla, CA 92093 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2012年 / 12卷 / 02期

基金：

美国国家卫生研究院;

关键词：

MESSENGER-RNA TRANSLATION; ACTIVATED PROTEIN-KINASE; IFN-GAMMA PRODUCTION; TOLL-LIKE RECEPTORS; CD8(+) T-CELLS; P70; S6; KINASE; ULCERATIVE-COLITIS; DENDRITIC CELLS; STAT4; ACTIVATION; GENE-EXPRESSION;

D O I：

10.1038/nri3133

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Interferon-alpha (IFN alpha) and IFN beta, collectively known as type I IFNs, are the major effector cytokines of the host immune response against viral infections. However, the production of type I IFNs is also induced in response to bacterial ligands of innate immune receptors and/or bacterial infections, indicating a broader physiological role for these cytokines in host defence and homeostasis than was originally assumed. The main focus of this Review is the underappreciated immunomodulatory functions of type I IFNs in health and disease. We discuss their function in the regulation of innate and adaptive immune responses, the response to bacterial ligands, inflammasome activation, intestinal homeostasis and inflammatory and autoimmune diseases.

引用

页码：125 / 135

页数：11

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