Peripheral B cell subsets

被引:382
作者
Allman, David [1 ]
Pillai, Shiv [2 ,3 ]
机构
[1] Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA
[2] Massachusetts Gen Hosp, Ctr Canc Res, Boston, MA 02129 USA
[3] Harvard Univ, Sch Med, Boston, MA 02129 USA
关键词
D O I
10.1016/j.coi.2008.03.014
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Our understanding of the origins and the biological functions of different peripheral B cell subsets continues to evolve. Some understanding has been obtained regarding the synergy between BCR-derived signals and other receptors and signaling pathways that drive the development of follicular, marginal zone, and B-1 B cells, but this remains a complex and poorly understood issue. More recent information regarding the origins of B-1 and B-2 B cells, the ability of follicular B cells to mature both in the bone marrow and the spleen, the existence of a definable precursor for MZ B cells, and the ability of follicular B cells to occupy two distinct niches are all highlighted in this review.
引用
收藏
页码:149 / 157
页数:9
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