Isolation and stereostructure of dolastatin I, a cytotoxic cyclic hexapeptide from the Japanese sea hare Dolabella auricularia

被引：46

作者：

Sone, H ^{[1
]}

Kigoshi, H ^{[1
]}

Yamada, K ^{[1
]}

机构：

[1] NAGOYA UNIV,FAC SCI,DEPT CHEM,NAGOYA,AICHI 464,JAPAN

来源：

TETRAHEDRON | 1997年 / 53卷 / 24期

基金：

日本学术振兴会;

关键词：

D O I：

10.1016/S0040-4020(97)00504-8

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Dolastatin I(1), a cyclic hexapeptide containing three kinds of five-membered heterocycles (oxazole, thiazole, and oxazoline), has been isolated from the Japanese sea hare Dolabella auricularia. The gross structure of 1 was elucidated by spectroscopic analysis. The absolute stereostructure of 1 was determined by chiral HPLC analysis of the amino acid components obtained by acid hydrolysis of 1. Dolastatin I(1) exhibited cytotoxicity against HeLa S-3 cells with an IC50 value of 12 mu g/mL. (C) 1997 Elsevier Science Ltd.

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收藏

页码：8149 / 8154

页数：6

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