Exposure assessment of French women and their newborn to brominated flame retardants: Determination of tri- to deca- polybromodiphenylethers (PBDE) in maternal adipose tissue, serum, breast milk and cord serum

被引:146
作者
Antignac, Jean-Philippe [1 ]
Cariou, Ronan [1 ]
Zalko, Daniel [2 ]
Berrebi, Alain [3 ]
Cravedi, Jean-Pierre [2 ]
Maume, Daniel [1 ]
Marchand, Philippe [1 ]
Monteau, Fabrice [1 ]
Riu, Anne [4 ]
Andre, Francois [1 ]
Le Bizec, Bruno [1 ]
机构
[1] ENVN, LABERCA, USC INRA 2013, F-44307 Nantes 3, France
[2] INRA, UMR Xenobiot 1089, F-31931 Toulouse, France
[3] Hop Paule Viguier, Ctr Hosp Univ Toulouse, Serv Gynecol Obstet, Toulouse, France
[4] Unite Signalisat Hormonale Environm & Canc, INSERM U824, F-34298 Montpellier 5, France
关键词
Mass spectrometry; Brominated flame retardants; Endocrine disruptors; Exposure assessment; Newborn; POLYBROMINATED DIPHENYL ETHERS; POLYCHLORINATED-BIPHENYLS; BLUE MUSSELS; FETAL BLOOD; SAMPLES; FISH; DE-71; MIXTURE; TREND;
D O I
10.1016/j.envpol.2008.07.008
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
In the frame of a French monitoring program, tri- to deca- polybromodiphenylethers (PBDE) have been measured in maternal and cord serum, adipose tissue, and breast milk samples, collected from 93 volunteer women during caesarean deliveries. The seven major tri- to heptaBDE (BDE-28, 47, 99,100,153, 154, and 183) were detected in adipose tissue and breast milk with cumulated median values of 2.59 and 2.51 ng g(-1) lw. Nine highly brominated octa- to decaBDE (BDE-196, 197, 201, 202, 203, 206, 207, 208 and 209) was performed in the same samples, with cumulated median values of 2.73 and 3.39 ng g(-1) lw in adipose tissue and breast milk, respectively. At this opposite, median levels of octa- to decaBDE in maternal and cord serum appeared significantly higher than the levels of tri- to heptaBDE in the same matrices, i.e. 8.85 and 12.34 versus 0.98 and 0.69 ng g(-1) lw, respectively. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码:164 / 173
页数:10
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