P′-extended α-ketoamide inhibitors of proteasome

被引:28
作者
Chattejee, S
Dunn, D
Mallya, S
Ator, MA
机构
[1] Cephalon Inc, Dept Chem, W Chester, PA 19380 USA
[2] Cephalon Inc, Dept Biochem, W Chester, PA 19380 USA
关键词
D O I
10.1016/S0960-894X(99)00443-6
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A series of potent P'-extended alpha-ketoamide inhibitors of chymotrypsin-like activity of proteasome is described. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:2603 / 2606
页数:4
相关论文
共 8 条
[1]   Novel inhibitors of the proteasome and their therapeutic use in inflammation [J].
Adams, J ;
Stein, R .
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 31, 1996, 31 :279-288
[2]   Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids [J].
Adams, J ;
Behnke, M ;
Chen, SW ;
Cruickshank, AA ;
Dick, LR ;
Grenier, L ;
Klunder, JM ;
Ma, YT ;
Plamondon, L ;
Stein, RL .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (04) :333-338
[3]   OXIDATION OF ALPHA-HYDROXY ESTERS TO ALPHA-KETO ESTERS USING THE DESS-MARTIN PERIODINANE REAGENT [J].
BURKHART, JP ;
PEET, NP ;
BEY, P .
TETRAHEDRON LETTERS, 1988, 29 (28) :3433-3436
[4]   STEREOSPECIFIC SYNTHESIS OF PEPTIDYL ALPHA-KETO AMIDES AS INHIBITORS OF CALPAIN [J].
HARBESON, SL ;
ABELLEIRA, SM ;
AKIYAMA, A ;
BARRETT, R ;
CARROLL, RM ;
STRAUB, JA ;
TKACZ, JN ;
WU, CC ;
MUSSO, GF .
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (18) :2918-2929
[5]   Potent alpha-ketocarbonyl and boronic ester derived inhibitors of proteasome [J].
Iqbal, M ;
Chatterjee, S ;
Kauer, JC ;
Mallamo, JP ;
Messina, PA ;
Reiboldt, A ;
Siman, R .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1996, 6 (03) :287-290
[6]   POTENT INHIBITORS OF PROTEASOME [J].
IQBAL, M ;
CHATTERJEE, S ;
KAUER, JC ;
DAS, M ;
MESSINA, P ;
FREED, B ;
BIAZZO, W ;
SIMAN, R .
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (13) :2276-2277
[7]   Selective inhibition of the chymotrypsin-like activity of the 20S proteasome by 5-methoxy-1-indanone dipeptide benzamides [J].
Lum, RT ;
Nelson, MG ;
Joly, A ;
Horsma, AG ;
Lee, G ;
Meyer, SM ;
Wick, MM ;
Schow, SR .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (03) :209-214
[8]   Inhibitors of the chymotrypsin-like activity of proteasome based on di- and tri-peptidyl α-keto aldehydes (glyoxals) [J].
Lynas, JF ;
Harriott, P ;
Healy, A ;
McKervey, MA ;
Walker, B .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1998, 8 (04) :373-378