Topology of three-way junctions in folded RNAs

被引：230

作者：

Lescoute, A ^{[1
]}

Westhof, E ^{[1
]}

机构：

[1] Univ Strasbourg, Inst Biol Mol & Cellulaire, UPR 9002, Architecture & React ARN,CNRS, F-67084 Strasbourg, France

来源：

RNA | 2006年 / 12卷 / 01期

关键词：

RNA motif; folding; tertiary contact; junction; RNA topology;

D O I：

10.1261/rna.2208106

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The three-way junctions contained in X-ray structures of folded RNAs have been compiled and analyzed. Three-way junctions with two helices approximately coaxially stacked can be divided into three main families depending on the relative lengths of the segments linking the three Watson-Crick helices. Each family has topological characteristics with some conservation in the non-Watson.-Crick pairs within the linking segments as well as in the types of contacts between the segments and the helices. The most populated family presents tertiary interactions between two helices as well as extensive shallow/minor groove contacts between a linking segment and the third helix. On the basis of the lengths of the linking segments, some guidelines could be deduced for choosing a topology for a three-way junction on the basis of a secondary structure. Examples and prediction based on those rules are discussed.

引用

页码：83 / 93

页数：11

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