Bringing next-generation therapeutics to the clinic through synthetic biology

被引：13

作者：

Bugaj, Lukasz J. ^{[1
,2
]}

Schaffer, David V. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Calif Berkeley, Dept Bioengn, Berkeley, CA 94720 USA

[2] Univ Calif Berkeley, UC Berkeley UCSF Grad Program Bioengn, Berkeley, CA 94720 USA

[3] Univ Calif Berkeley, Dept Chem Engn, Berkeley, CA 94720 USA

[4] Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USA

[5] Univ Calif Berkeley, Calif Inst Quantitat Biosci, Berkeley, CA 94720 USA

来源：

CURRENT OPINION IN CHEMICAL BIOLOGY | 2012年 / 16卷 / 3-4期

关键词：

ESCHERICHIA-COLI NISSLE-1917; T-CELL PROLIFERATION; GENE-THERAPY; SALMONELLA-TYPHIMURIUM; MAMMALIAN-CELLS; PHASE-I; TRANSGENE EXPRESSION; CANCER; BACTERIA; TUMORS;

D O I：

10.1016/j.cbpa.2012.04.009

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Recent advances in synthetic biology have created genetic tools with the potential to enhance the specificity, dynamic control, efficacy, and safety of medical treatments. Interfacing these genetic devices with human patients may thus bring about more efficient treatments or entirely new solutions to presently intractable maladies. Here we review engineered circuits with clinical potential and discuss their design, implementation, and validation.

引用

页码：355 / 361

页数：7

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