Strategy for ensuring a better future for the vessel wall

被引:8
作者
Corti, R [1 ]
Fuster, V [1 ]
Badimon, JJ [1 ]
机构
[1] Mt Sinai Sch Med, Zena & Michael A Wiener Cardiovasc Inst, New York, NY 10029 USA
关键词
cardiovascular diseases; atherosclerosis; lipids; thrombosis; thrombolysis;
D O I
10.1016/S1520-765X(02)90071-4
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Prevention of cardiovascular events should involve an adequate control of the risk factors (diabetes, blood pressure, hyperlipidemia, etc). Once the thrombotic complications occur. the invasive approaches combined with potent antithrombotic agents appears to have some advantage over fibrinolytic therapy. A need for better and more efficacious antithrombotics is indicated by the high incidence of thrombotic complications. Among the new antothrombotic agents, the inhibition of the TF pathway (inhibitors of factors VIIa, Xa or oral thrombin inhibitors) seems to be more promising. Their efficacy should be demonstrated in large and controlled clinical trials. (C) 2002 The European Society of Cardiology.
引用
收藏
页码:A31 / A41
页数:11
相关论文
共 54 条
[31]   Increased thrombus formation relates to ambient blood glucose and leukocyte count in diabetes mellitus type 2 [J].
Rauch, U ;
Crandall, J ;
Osende, JI ;
Fallon, JT ;
Chesebro, JH ;
Fuster, V ;
Badimon, JJ .
AMERICAN JOURNAL OF CARDIOLOGY, 2000, 86 (02) :246-249
[32]   Relation of gemfibrozil treatment and lipid levels with major coronary events - VA-HIT: A randomized controlled trial [J].
Robins, SJ ;
Collins, D ;
Wittes, JT ;
Papademetriou, V ;
Deedwania, PC ;
Schaefer, EJ ;
McNamara, JR ;
Kashyap, ML ;
Hershman, JM ;
Wexler, LF ;
Rubins, HB .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (12) :1585-1591
[33]   Elevating high-density lipoprotein cholesterol in apolipoprotein E-deficient mice remodels advanced atherosclerotic lesions by decreasing macrophage and increasing smooth muscle cell content [J].
Rong, JX ;
Li, J ;
Reis, ED ;
Choudhury, RP ;
Dansky, HM ;
Elmalem, VI ;
Fallon, JT ;
Breslow, JL ;
Fisher, EA .
CIRCULATION, 2001, 104 (20) :2447-2452
[34]   Inhibition of tissue factor reduces thrombus formation and intimal hyperplasia after porcine coronary angioplasty [J].
Roqué, M ;
Reis, ED ;
Fuster, V ;
Padurean, A ;
Fallon, JT ;
Taubman, MB ;
Chesebro, JH ;
Badimon, JJ .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2000, 36 (07) :2303-2310
[35]   Extended mortality benefit of early postinfarction reperfusion [J].
Ross, AM ;
Coyne, KS ;
Moreyra, E ;
Reiner, JS ;
Greenhouse, SW ;
Walker, PL ;
Simoons, ML ;
Draoui, YC ;
Califf, RM ;
Topol, EJ ;
Van de Werf, F ;
Lundergan, CF .
CIRCULATION, 1998, 97 (16) :1549-1556
[36]   Mechanisms of disease - Atherosclerosis - An inflammatory disease [J].
Ross, R .
NEW ENGLAND JOURNAL OF MEDICINE, 1999, 340 (02) :115-126
[37]  
SARICH TC, 2001, THROMB HAEMOSTASIS, V86, pC2391
[38]   Secondary prevention by raising HDL cholesterol and reducing triglycerides in patients with coronary artery disease - The bezafibrate infarction prevention (BIP) study [J].
Schlesinger, Z ;
Vered, Z ;
Friedenson, A ;
Reisin, L ;
Jafari, J ;
Flieb, T ;
Sclarovsky, S ;
Friedman, Y ;
Ostfeld, B ;
Solodky, A ;
Abinader, E ;
Rochfleish, S ;
Palant, A ;
Schneider, H ;
Rosenfeld, T ;
Khalid, S ;
Wolfson, E ;
Kishon, Y ;
Narinsky, R ;
Rotzak, R ;
Davidov, A ;
Levine, G ;
Zahavi, I ;
Vitrai, J ;
Diker, D ;
Pelled, B ;
Pardu, J ;
Galamidi, J ;
Majadla, R ;
Laniado, S ;
Sherf, L ;
Braun, S ;
Eschar, Y ;
Caspi, A ;
Arditi, A ;
Botwin, S ;
Arkavi, L ;
Ziv, M ;
David, D ;
Weisenberg, D ;
Kohanovski, M ;
Meisel, S ;
Rougin, N ;
Yahalom, M ;
Glusman-Vazan, A ;
Markiewitz, W ;
Motlak, D ;
Lessick, J ;
Kagan, G ;
Marmour, A .
CIRCULATION, 2000, 102 (01) :21-27
[39]   Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes - The MIRACL study: A randomized controlled trial [J].
Schwartz, GG ;
Olsson, AG ;
Ezekowitz, MD ;
Ganz, P ;
Oliver, MF ;
Waters, D ;
Zeiher, A ;
Chaitman, BR ;
Leslie, S ;
Stern, T .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2001, 285 (13) :1711-1718
[40]  
SHIMBO D, 2001, THROMB HAEMOSTASIS, V86, pP1392