CellProfiler Analyst: data exploration and analysis software for complex image-based screens

被引：405

作者：

Jones, Thouis R. ^{[1
,2
,3
]}

Kang, In Han ^{[3
]}

Wheeler, Douglas B. ^{[2
]}

Lindquist, Robert A. ^{[2
]}

Papallo, Adam ^{[1
,2
]}

Sabatini, David M. ^{[2
,4
]}

Golland, Polina ^{[3
]}

Carpenter, Anne E. ^{[1
,2
]}

机构：

[1] MIT & Harvard, Broad Inst, Cambridge, MA 02142 USA

[2] Whitehead Inst Biomed Res, Cambridge, MA 02142 USA

[3] MIT, Comp Sci & Artificial Intelligence Lab, Cambridge, MA 02142 USA

[4] MIT, Dept Biol, Cambridge, MA 02142 USA

来源：

BMC BIOINFORMATICS | 2008年 / 9卷 / 1期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1186/1471-2105-9-482

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Background: Image-based screens can produce hundreds of measured features for each of hundreds of millions of individual cells in a single experiment. Results: Here, we describe CellProfiler Analyst, open-source software for the interactive exploration and analysis of multidimensional data, particularly data from high-throughput, image-based experiments. Conclusion: The system enables interactive data exploration for image-based screens and automated scoring of complex phenotypes that require combinations of multiple measured features per cell.

引用

页数：16

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