Monophosphate as eminent ligand to bind Ce(IV)/EDTA complex for site-selective DNA hydrolysis

被引：6

作者：

Chen, W ^{[1
]}

Igawa, T ^{[1
]}

Sumaoka, J ^{[1
]}

Komiyama, M ^{[1
]}

机构：

[1] Univ Tokyo, Adv Sci & Technol Res Ctr, Meguro Ku, Tokyo 1538904, Japan

来源：

CHEMISTRY LETTERS | 2004年 / 33卷 / 03期

关键词：

D O I：

10.1246/cl.2004.300

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

By the use of oligonuclelotides bearing a terminal monophosphate, 10-base gap was formed in substrate DNA and the monophosphates were placed at the edge of gap. Upon the treatment of these systems with Ce(IV)/EDTA complex, the gap-site was selectively hydrolyzed. The monophosphates remarkably promoted both the selectivity and the efficiency of scission.

引用

页码：300 / 301

页数：2

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