Virology - Clues to the virulence of H5N1 viruses in humans

被引：29

作者：

Krug, RM ^{[1
]}

机构：

[1] Univ Texas, Inst Mol & Cellular Biol, Austin, TX 78712 USA

来源：

SCIENCE | 2006年 / 311卷 / 5767期

关键词：

D O I：

10.1126/science.1125998

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Why is H5N1 avian influenza so virulent? Genomic analysis of various isolates suggests that, in addition to two known surface proteins, a third previously unnoticed sequence in a small viral protein may contribute to virulence.

引用

页码：1562 / 1563

页数：2

共 11 条

[1] Biophysical characterization of the complex between double-stranded RNA and the N-terminal domain of the NS1 protein from influenza A virus: Evidence for a novel RNA-binding mode [J].

Chien, CY ;

Xu, YJ ;

Xiao, R ;

Aramini, JM ;

Sahasrabudhe, PV ;

Krug, RM ;

Montelione, GT .

BIOCHEMISTRY, 2004, 43 (07) :1950-1962

[2] Inhibition of interferon-mediated antiviral responses by influenza A viruses and other negative-strand RNA viruses [J].

García-Sastre, A .

VIROLOGY, 2001, 279 (02) :375-384

[3] Lethality to ferrets of H5N1 influenza viruses isolated from humans and poultry in 2004 [J].

Govorkova, EA ;

Rehg, JE ;

Krauss, S ;

Yen, HL ;

Guan, Y ;

Peiris, M ;

Nguyen, TD ;

Hanh, TH ;

Puthavathana, P ;

Long, HT ;

Buranathai, C ;

Lim, W ;

Webster, RG ;

Hoffmann, E .

JOURNAL OF VIROLOGY, 2005, 79 (04) :2191-2198

[4] Molecular basis for high virulence of Hong Kong H5N1 influenza A viruses [J].

Hatta, M ;

Gao, P ;

Halfmann, P ;

Kawaoka, Y .

SCIENCE, 2001, 293 (5536) :1840-1842

[5] Influenza: Lessons from past pandemics, warnings from current incidents [J].

Horimoto, T ;

Kawaoka, Y .

NATURE REVIEWS MICROBIOLOGY, 2005, 3 (08) :591-600

[6] Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein [J].

Krug, RM ;

Yuan, WM ;

Noah, DL ;

Latham, AG .

VIROLOGY, 2003, 309 (02) :181-189

[7]

Lamb RA, 2001, FIELDS VIROLOGY, P1487, DOI DOI 10.1038/CR.2017.129

[8] Influenza virus virulence and its molecular determinants [J].

Noah, DL ;

Krug, RM .

ADVANCES IN VIRUS RESEARCH, VOL 65, 2005, 65 :121-+

[9] Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS [J].

Noah, DL ;

Twu, KY ;

Krug, RM .

VIROLOGY, 2003, 307 (02) :386-395

[10] Large-scale sequence analysis of avian influenza isolates [J].

Obenauer, JC ;

Denson, J ;

Mehta, PK ;

Su, XP ;

Mukatira, S ;

Finkelstein, DB ;

Xu, XQ ;

Wang, JH ;

Ma, J ;

Fan, YP ;

Rakestraw, KM ;

Webster, RG ;

Hoffmann, E ;

Krauss, S ;

Zheng, J ;

Zhang, ZW ;

Naeve, CW .

SCIENCE, 2006, 311 (5767) :1576-1580

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