Mitochondria as targets for chemotherapy

被引：116

作者：

Gogvadze, Vladimir ^{[1
]}

Orrenius, Sten ^{[1
]}

Zhivotovsky, Boris ^{[1
]}

机构：

[1] Karolinska Inst, Inst Environm Med, Div Toxicol, S-17177 Stockholm, Sweden

来源：

APOPTOSIS | 2009年 / 14卷 / 04期

基金：

瑞典研究理事会;

关键词：

Mitochondria; Disease; Oxidative stress; Neurodegeneration; Cancer; CYTOCHROME-C RELEASE; PERMEABILITY TRANSITION PORE; MOTOR-NEURON DEGENERATION; PROGRAMMED CELL-DEATH; COENZYME Q(10); CYCLOPHILIN-D; SUPEROXIDE-DISMUTASE; OXIDATIVE STRESS; DRUG-RESISTANCE; CANCER-CELLS;

D O I：

10.1007/s10495-009-0323-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondrial malfunctioning is implicated in the pathogenesis of a variety of disorders, including cancer and multiple neurodegenerative diseases, such as Parkinson's disease, Alzheimer's disease, amyotrophic lateral sclerosis, and Huntington's disease. Disturbance of mitochondrial vital functions, e.g., production of ATP, calcium buffering capacity, and generation of reactive oxygen species, can be potentially involved in disease pathogenesis. Neurological disorders caused by mitochondrial deterioration are often associated with cell loss within specific brain regions. In contrast, mitochondrial alterations in tumor cells and the "Warburg effect" might lead to cell survival and resistance of tumor cells to chemotherapy. This review is devoted to the role of mitochondria in neurodegeneration and tumor formation, and describes how targeting of mitochondria can be beneficial in the therapy of these diseases, which affect a large human population.

引用

页码：624 / 640

页数：17

共 128 条

[1] Imbalance of the mitochondrial pro- and anti-apoptotic mediators in neuroblastoma tumours with unfavourable biology [J].

Abel, F ;

Sjöberg, RM ;

Nilsson, S ;

Kogner, P ;

Martinsson, T .

EUROPEAN JOURNAL OF CANCER, 2005, 41 (04) :635-646

[2] Hexokinase-I protection against apoptotic cell death is mediated via interaction with the voltage-dependent anion channel-1 - Mapping the site of binding [J].

Abu-Hamad, Salah ;

Zaid, Hilal ;

Israelson, Adrian ;

Nahon, Edna ;

Shoshan-Barmatz, Varda .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 283 (19) :13482-13490

[3] Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutations [J].

Amiott, Elizabeth A. ;

Lott, Paul ;

Soto, Jamie ;

Kang, Peter B. ;

McCaffery, J. Michael ;

DiMauro, Salvatore ;

Abel, E. Dale ;

Flanigan, Kevin M. ;

Lawson, Victoria H. ;

Shaw, Janet M. .

EXPERIMENTAL NEUROLOGY, 2008, 211 (01) :115-127

[4] Creatine supplementation improves dopaminergic cell survival and protects against MPP+ toxicity in an organotypic tissue culture system [J].

Andres, RH ;

Ducray, AD ;

Pérez-Bouza, A ;

Schlattner, U ;

Huber, AW ;

Krebs, SH ;

Seiler, RW ;

Wallimann, T ;

Widmer, HR .

CELL TRANSPLANTATION, 2005, 14 (08) :537-550

[5] Mitochondrial metabolism of reactive oxygen species [J].

Andreyev, AI ;

Kushnareva, YE ;

Starkov, AA .

BIOCHEMISTRY-MOSCOW, 2005, 70 (02) :200-214

[6] GLUTAMATE-INDUCED NEURONAL DEATH - A SUCCESSION OF NECROSIS OR APOPTOSIS DEPENDING ON MITOCHONDRIAL-FUNCTION [J].

ANKARCRONA, M ;

DYPBUKT, JM ;

BONFOCO, E ;

ZHIVOTOVSKY, B ;

ORRENIUS, S ;

LIPTON, SA ;

NICOTERA, P .

NEURON, 1995, 15 (04) :961-973

[7] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 1. Cationic plastoquinone derivatives: Synthesis and in vitro studies [J].

Antonenko, Y. N. ;

Avetisyan, A. V. ;

Bakeeva, L. E. ;

Chernyak, B. V. ;

Chertkov, V. A. ;

Domnina, L. V. ;

Ivanova, O. Yu. ;

Izyumov, D. S. ;

Khailova, L. S. ;

Klishin, S. S. ;

Korshunova, G. A. ;

Lyamzaev, K. G. ;

Muntyan, M. S. ;

Nepryakhina, O. K. ;

Pashkovskaya, A. A. ;

Pletjushkina, O. Yu. ;

Pustovidko, A. V. ;

Roginsky, V. A. ;

Rokitskaya, T. I. ;

Ruuge, E. K. ;

Saprunova, V. B. ;

Severina, I. I. ;

Simonyan, R. A. ;

Skulachev, I. V. ;

Skulachev, M. V. ;

Sumbatyan, N. V. ;

Sviryaeva, I. V. ;

Tashlitsky, V. N. ;

Vassiliev, J. M. ;

Vyssokikh, M. Yu. ;

Yaguzhinsky, L. S. ;

Zamyatnin, A. A., Jr. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1273-1287

[8] Amyloid-β peptide binds with heme to form a peroxidase:: Relationship to the cytopathologies of Alzheimer's disease [J].

Atamna, H ;

Boyle, K .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (09) :3381-3386

[9] Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the aging program. 2. Treatment of some ROS- and Age-related diseases (heart arrhythmia, heart infarctions, kidney ischemia, and stroke) [J].

Bakeeva, L. E. ;

Barskov, I. V. ;

Egorov, M. V. ;

Isaev, N. K. ;

Kapelko, V. I. ;

Kazachenko, A. V. ;

Kirpatovsky, V. I. ;

Kozlovsky, S. V. ;

Lakomkin, V. L. ;

Levina, S. B. ;

Pisarenko, O. I. ;

Plotnikov, E. Y. ;

Saprunova, V. B. ;

Serebryakova, L. I. ;

Skulachev, M. V. ;

Stelmashook, E. V. ;

Studneva, I. M. ;

Tskitishvili, O. V. ;

Vasilyeva, A. K. ;

Victorov, I. V. ;

Zorov, D. B. ;

Skulachev, V. P. .

BIOCHEMISTRY-MOSCOW, 2008, 73 (12) :1288-1299

[10] COENZYME Q(10) AND NICOTINAMIDE BLOCK STRIATAL LESIONS PRODUCED BY THE MITOCHONDRIAL TOXIN MALONATE [J].

BEAL, MF ;

HENSHAW, DR ;

JENKINS, BG ;

ROSEN, BR ;

SCHULZ, JB .

ANNALS OF NEUROLOGY, 1994, 36 (06) :882-888

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