Ionic Liquid-Supported (ILS) (S)-Pyrrolidine Sulfonamide, a Recyclable Organocatalyst for the Highly Enantioselective Michael Addition to Nitroolefins

被引：102

作者：

Ni, Bukuo ^{[1
]}

Zhang, Qianying ^{[1
]}

Dhungana, Kritanjali ^{[1
]}

Headley, Allan D. ^{[1
]}

机构：

[1] Texas A&M Univ, Dept Chem, Commerce, TX 75429 USA

来源：

ORGANIC LETTERS | 2009年 / 11卷 / 04期

基金：

美国国家科学基金会;

关键词：

ASYMMETRIC CONJUGATE ADDITION; KETONES; ALDEHYDES; CATALYSTS; NITROSTYRENES; NITROALKANES; DERIVATIVES;

D O I：

10.1021/ol900003e

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new class of ionic liquid supported (ILS) (S)-pyrrolidine sulfonamide organocatalyst has been developed and shown to be a very effective catalyst for the asymmetric Michael addition reactions of ketones and aldehyde to nitroolefins with high enantio- and diastereoselectivities. This ILS organocatalyst is also easily recycled and could be reused at least five times without significant loss of its ability to affect the outcome of the asymmetric reactions.

引用

页码：1037 / 1040

页数：4

共 51 条

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