High-performance liquid chromatographic analysis of cyclosporin A and its oral solutions

被引：21

作者：

Husek, A

机构：

[1] Galena Co., Department of Analytical Chemistry, R and D, 747 70 Opava-Komárov

来源：

JOURNAL OF CHROMATOGRAPHY A | 1997年 / 759卷 / 1-2期

关键词：

pharmaceutical analysis; cyclosporins;

D O I：

10.1016/S0021-9673(96)00770-4

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Different columns and conditions were evaluated for the HPLC analysis of cyclosporin A, its congeners and degradation products. The optimised conditions were compared with the pharmacopoeial HPLC method for cyclosporin A analysis and some modifications, applicable among others for the stability studies of oral dosage forms, are proposed.

引用

页码：217 / 224

页数：8

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