Absence of Δ-9-tetrahydrocannabinol dysphoric effects in dynorphin-deficient mice

被引：113

作者：

Zimmer, A

Valjent, E

König, M

Zimmer, AM

Robledo, P

Hahn, H

Valverde, O

Maldonado, R

机构：

[1] Univ Bonn, Psychiat Clin, D-53105 Bonn, Germany

[2] NIMH, Genet Lab, Bethesda, MD 20892 USA

[3] Univ Pompeu Fabra, Fac Ciencies Salut & Vida, Lab Neurofarmacol, Barcelona 08003, Spain

来源：

JOURNAL OF NEUROSCIENCE | 2001年 / 21卷 / 23期

关键词：

cannabinoid; opioid; mice; mutation; withdrawal; addiction; place aversion;

D O I：

10.1523/JNEUROSCI.21-23-09499.2001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The involvement of dynorphin on Delta -9-tetrahydrocannabinol (THC) and morphine responses has been investigated by using mice with a targeted inactivation of the prodynorphin (Pdyn) gene. Dynorphin-deficient mice show specific changes in the behavioral effects of THC, including a reduction of spinal THC analgesia and the absence of THC-induced conditioned place aversion. In contrast, acute and chronic opioid effects were normal. The lack of negative motivational effects of THC in the absence of dynorphin demonstrates that this endogenous opioid peptide mediates the dysphoric effects of marijuana.

引用

页码：9499 / 9505

页数：7

共 61 条

[41] A role for central cannabinoid and opioid systems in peripheral Delta(9)-tetrahydrocannabinol-induced analgesia in mice (vol 301, pg 75, 1996) [J].