Occurrence of aminoglycoside-modifying-enzyme genes aac(6′)-aph(2"), aph(3′ ), ant(4′) and ant(6) in clinical isolates of Enterococcus faecalis resistant to high-level of gentamicin and amikacin

被引：11

作者：

Filipova, M.

Bujdakova, H. ^{[1
]}

Drahovska, H.

Liskova, A.

Hanzen, J.

机构：

[1] Comenius Univ, Fac Sci, Dept Microbiol & Virol, Bratislava 84215, Slovakia

[2] Comenius Univ, Fac Sci, Dept Mol Biol, Bratislava 84215, Slovakia

[3] HPL, Lab Clin Microbiol, Bratislava, Slovakia

来源：

FOLIA MICROBIOLOGICA | 2006年 / 51卷 / 01期

关键词：

D O I：

10.1007/BF02931451

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The genes coding for 4 aminoglycoside-modifying enzymes AAC(6')-APH(2"), APH(3'), ANT(4') and ANT(6) were determined in 44 Slovak clinical isolates of Enterococcus faecalis with high-level resistance to gentamicin (HLGR, collection 1) and 48 E.faecalis isolates with resistance to amikacin (AR, collection 2). The occurrence of spotted genes was (collection 1 vs. collection 2): aac(6')-aph(2") 81.8 vs. 8.3%, ant(4') 52.3 vs. 81.3%, aph(3') 50 vs. 56.3% and ant(6') 6.8 vs. 4.2%, the most frequent combinations of genes in the HLGR collection were aac(6')-aph(2") + ant(4') and aac(6')-aph(2") + aph(3'). In contrast, the aph(3') + ant(4") gene profile was predominant in AR isolates. None of the isolates contained all four AGME genes simultaneously.

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页码：57 / 61

页数：5

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