Fetal dopaminergic transplantation trials and the future of neural grafting in Parkinson's disease

被引：273

作者：

Barker, Roger A. ^{[1
]}

Barrett, Jessica ^{[2
]}

Mason, Sarah L. ^{[1
]}

Bjorklund, Anders ^{[3
]}

机构：

[1] Cambridge Ctr Brain Repair, Cambridge CB2 0PY, England

[2] Inst Publ Hlth, MRC Biostat Unit, Cambridge, England

[3] Lund Univ, Div Neurobiol, Wallenberg Neurosci Ctr, S-22184 Lund, Sweden

来源：

LANCET NEUROLOGY | 2013年 / 12卷 / 01期

关键词：

CORE ASSESSMENT PROGRAM; DOPA-INDUCED DYSKINESIA; LONG-TERM SURVIVAL; DOUBLE-BLIND; VENTRAL MESENCEPHALON; NIGRAL TRANSPLANTS; CAUDATE-NUCLEUS; FOLLOW-UP; INTRASTRIATAL TRANSPLANTATION; CELL TRANSPLANTATION;

D O I：

10.1016/S1474-4422(12)70295-8

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Clinical use of allografts of fetal ventral mesencephalic tissue as a treatment to replace dopaminergic neurons in patients with Parkinson's disease was first done more than 20 years ago. Since then, many patients have received transplants, with variable results. During this time, our knowledge of Parkinson's disease has changed and the nature and extent of problems associated with the disorder have been better defined. Our understanding on how best to implement this cell-replacement strategy for patients has grown, but gaining this insight has entailed critical reappraisal of data from transplant trials that have already been undertaken.

引用

页码：84 / 91

页数：8

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