CASH -: a β-helix domain widespread among carbohydrate-binding proteins

被引：27

作者：

Ciccarelli, FD

Copley, RR

Doerks, T

Russell, RB

Bork, P

机构：

[1] Max Delbrueck Centrum, D-13092 Berlin, Germany

[2] European Mol Biol Lab, D-69012 Heidelberg, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2002年 / 27卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(01)02046-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In this article, we describe a novel, widespread domain (CASH) that is shared by many carbohydrate-binding proteins and sugar hydrolases. This domain occurs in more than 1000 proteins distributed among all three kingdoms of life. The CASH domain is characterized by internal repetitions of glycines and hydrophobic residues that correspond to the repetitive units of a predicted or observed right-handed beta-helix structure of the pectate lyase superfamily.

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页码：59 / 62

页数：4

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