Sox2 expression predicts poor survival of hepatocellular carcinoma patients and it promotes liver cancer cell invasion by activating Slug

被引：98

作者：

Sun, Chun ^{[1
,2
]}

Sun, Lu

Li, Yan ^{[1
]}

Kang, Xiaonan ^{[2
]}

Zhang, Shu ^{[1
,2
]}

Liu, Yinkun ^{[1
,2
]}

机构：

[1] Fudan Univ, Liver Canc Inst, Zhongshan Hosp, Shanghai 200032, Peoples R China

[2] Fudan Univ, Canc Res Ctr, Inst Biomed Sci, Shanghai 200032, Peoples R China

来源：

MEDICAL ONCOLOGY | 2013年 / 30卷 / 02期

关键词：

Sox2; Slug; EMT; Metastasis; Hepatocellular carcinoma; TO-MESENCHYMAL TRANSITION; NANOG; METASTASIS; INCREASES; PROGNOSIS; TWIST1; OCT4;

D O I：

10.1007/s12032-013-0503-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Sox2 is a major transcription factor essential to the stemness characteristics and is associated with various types of cancers. In this study, we investigated the expressions and functional roles of Sox2 in hepatocellular carcinoma (HCC). Our data show that high level of Sox2 expression correlates with metastasis and low survival rate in HCC. HCC cells overexpressing Sox2 are characterized by active epithelial-mesenchymal transition and exhibit increased ability of transwell invasion, soft agar colonization, and sphere formation. We also found Sox2 expression was correlated with the transcription activity of SLUG promoter region. These results present novel mechanistic insight into an important role of Sox2 in HCC and suggest a potential application of Sox2 in HCC prognosis and treatment.

引用

页数：10

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