Immunotoxins in cancer therapy

被引:179
作者
Kreitman, RJ [1 ]
机构
[1] NCI, Div Canc Biol, Mol Biol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1016/S0952-7915(99)00005-9
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Immunotoxins are composed of a protein toxin connected to a binding ligand such as an antibody or growth factor. These molecules hind to surface antigens (which internalize) and kill cells by catalytic inhibition of protein synthesis within the cell cytosol. Immunotoxins have recently been tested clinically in hematologic malignancies and solid tumors and have demonstrated potent clinical efficacy in patients with malignant diseases that are refractory to surgery, radiation therapy and chemotherapy - the traditional modalities of cancer treatment. This therapy is thus evolving into a separate modality of cancer treatment. capable of rationally targeting cells on the basis of surface markers. Efforts are underway to obviate impediments to clinical efficacy, including immunogenicity and toxicity to normal tissues. Immunotoxins are now being developed to new antigens for the treatment of cancer.
引用
收藏
页码:570 / 578
页数:9
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