Human herpesvirus 6 is latent in peripheral blood of patients with relapsing-remitting multiple sclerosis

被引：24

作者：

Rotola, A

Cassai, E

Tola, MR

Granieri, E

Di Luca, D

机构：

[1] Univ Ferrara, Dept Expt & Diagnost Med, Microbiol Sect, I-44100 Ferrara, Italy

[2] Univ Ferrara, Med & surg Disciplines, Neurol Sect, I-44100 Ferrara, Italy

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1999年 / 67卷 / 04期

关键词：

multiple sclerosis; HHV-6; transcription;

D O I：

10.1136/jnnp.67.4.529

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Studies of the association between HHV-6 and multiple sclerosis are hindered by the difficulty in discriminating between latent and active infection. A follow up study was undertaken of patients with multiple sclerosis, searching peripheral blood mononuclear cells for molecular markers associated with HHV-6 latency and lytic replication. The results show that HHV-6 is latent and did not support systemic infection in patients with multiple sclerosis. Likewise, patients with multiple sclerosis did not show any evidence of active infection with other human herpesviruses HHV-7 and HHV-8.

引用

页码：529 / 531

页数：3