Engineering large animal models of human disease

被引：103

作者：

Whitelaw, C. Bruce A. ^{[1
,2
]}

Sheets, Timothy P. ^{[3
,4
]}

Lillico, Simon G. ^{[1
,2
]}

Telugu, Bhanu P. ^{[3
,4
]}

机构：

[1] Univ Edinburgh, Roslin Inst, Edinburgh EH25 9RG, Midlothian, Scotland

[2] Univ Edinburgh, Royal Dick Sch Vet Sci, Edinburgh EH25 9RG, Midlothian, Scotland

[3] ARS, Anim Biosci & Biotechnol Lab, Beltsville, MD 20705 USA

[4] Dept Anim & Avian Sci, Beltsville, MD 20742 USA

来源：

JOURNAL OF PATHOLOGY | 2016年 / 238卷 / 02期

基金：

英国生物技术与生命科学研究理事会;

关键词：

CRISPR; gene editing; livestock; pathology; pigs; SCNT; TALEN; ZFN; zygote; ZINC-FINGER NUCLEASES; HOMOLOGY-DIRECTED REPAIR; MONO-ALLELIC KNOCKOUT; ONE-STEP GENERATION; CYSTIC-FIBROSIS; HUNTINGTONS-DISEASE; BIALLELIC KNOCKOUT; TRANSGENIC MICE; MOUSE MODELS; EFFICIENT GENERATION;

D O I：

10.1002/path.4648

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The recent development of gene editing tools and methodology for use in livestock enables the production of new animal disease models. These tools facilitate site-specific mutation of the genome, allowing animals carrying known human disease mutations to be produced. In this review, we describe the various gene editing tools and how they can be used for a range of large animal models of diseases. This genomic technology is in its infancy but the expectation is that through the use of gene editing tools we will see a dramatic increase in animal model resources available for both the study of human disease and the translation of this knowledge into the clinic. Comparative pathology will be central to the productive use of these animal models and the successful translation of new therapeutic strategies. (c) 2015 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.

引用

页码：247 / 256

页数：10

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